Clinical Features of Adult COVID-19 Patients without Risk Factors before and after the Nationwide SARS-CoV-2 B.1.617.2 (Delta)-variant Outbreak in Korea : Experience from Gyeongsangnam-do
© 2021 The Korean Academy of Medical Sciences..
BACKGROUND: Data on severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) delta variant virulence are insufficient. We retrospectively compared the clinical features of adult coronavirus disease 2019 (COVID-19) patients without risk factors for severe COVID-19 who entered residential treatment centers (RTCs) before and after the delta variant outbreak.
METHODS: We collected medical information from two RTCs in South Korea. On the basis of nationwide delta variant surveillance, we divided the patients into two groups: 1) the delta-minor group (diagnosed from December 2020-June 2021, detection rate < 10%) and 2) the delta-dominant group (diagnosed during August 2021, detection rate > 90%). After propensity-score matching, the incidences of pneumonia, hospital transfer and need for supplemental oxygen were compared between the groups. In addition, risk factors for hospital transfer were analysed.
RESULTS: A total of 1,915 patients were included. The incidence of pneumonia (14.6% vs. 9.2%, P = 0.009), all-cause hospital transfer (10.4% vs. 6.3%, P = 0.020) and COVID-19-related hospital transfer (7.5% vs. 4.8%, P = 0.081) were higher in the delta-dominant group than those in the delta-minor group. In the multivariate analysis, the delta-dominant group was an independent risk factor for all-cause (adjusted odds ratio [aOR], 1.91; 95% confidence interval [CI], 1.16-3.13; P = 0.011) and COVID-19-related hospital transfer (aOR, 1.86; 95% CI, 1.04-3.32; P = 0.036).
CONCLUSION: Hospitalization rates were increased in the adult COVID-19 patients during the delta variant nationwide outbreak. Our results showed that the delta variant may be more virulent than previous lineages.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
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| Enthalten in: |
Journal of Korean medical science - 36(2021), 49 vom: 20. Dez., Seite e341 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ryu, Byung-Han [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 07.01.2022 Date Revised 04.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3346/jkms.2021.36.e341 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM334675154 |
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| 100 | 1 | |a Ryu, Byung-Han |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical Features of Adult COVID-19 Patients without Risk Factors before and after the Nationwide SARS-CoV-2 B.1.617.2 (Delta)-variant Outbreak in Korea |b Experience from Gyeongsangnam-do |
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| 500 | |a Date Revised 04.04.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 The Korean Academy of Medical Sciences. | ||
| 520 | |a BACKGROUND: Data on severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) delta variant virulence are insufficient. We retrospectively compared the clinical features of adult coronavirus disease 2019 (COVID-19) patients without risk factors for severe COVID-19 who entered residential treatment centers (RTCs) before and after the delta variant outbreak | ||
| 520 | |a METHODS: We collected medical information from two RTCs in South Korea. On the basis of nationwide delta variant surveillance, we divided the patients into two groups: 1) the delta-minor group (diagnosed from December 2020-June 2021, detection rate < 10%) and 2) the delta-dominant group (diagnosed during August 2021, detection rate > 90%). After propensity-score matching, the incidences of pneumonia, hospital transfer and need for supplemental oxygen were compared between the groups. In addition, risk factors for hospital transfer were analysed | ||
| 520 | |a RESULTS: A total of 1,915 patients were included. The incidence of pneumonia (14.6% vs. 9.2%, P = 0.009), all-cause hospital transfer (10.4% vs. 6.3%, P = 0.020) and COVID-19-related hospital transfer (7.5% vs. 4.8%, P = 0.081) were higher in the delta-dominant group than those in the delta-minor group. In the multivariate analysis, the delta-dominant group was an independent risk factor for all-cause (adjusted odds ratio [aOR], 1.91; 95% confidence interval [CI], 1.16-3.13; P = 0.011) and COVID-19-related hospital transfer (aOR, 1.86; 95% CI, 1.04-3.32; P = 0.036) | ||
| 520 | |a CONCLUSION: Hospitalization rates were increased in the adult COVID-19 patients during the delta variant nationwide outbreak. Our results showed that the delta variant may be more virulent than previous lineages | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Delta Variant | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a South Korea | |
| 650 | 4 | |a Virulence | |
| 700 | 1 | |a Hong, Sun In |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Su Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Younghwa |e verfasserin |4 aut | |
| 700 | 1 | |a Hwang, Cheolgu |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Hyungseok |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Si-Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Wi, Yu Mi |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Kyung-Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Bae, In-Gyu |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, Oh-Hyun |e verfasserin |4 aut | |
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