Placental characteristics and risks of maternal mortality 50 years after delivery
Copyright © 2021. Published by Elsevier Ltd..
INTRODUCTION: Adverse pregnancy outcomes such as preterm delivery and preeclampsia are associated with a higher maternal risk for subsequent cardiovascular disease (CVD) and all-cause mortality. While such pregnancy conditions are related to abnormal placentation, little research has investigated whether pathologic placental measures could serve as a risk factor for future CVD mortality in mothers.
METHODS: Longitudinal study of 33,336 women from the Collaborative Perinatal Project (CPP; 1959-1966) linked to mortality information through December 2016. Pathologists took extensive morphological and histopathological measures. Apart from assessing associations with morphological features, we derived an overall composite score and specific inflammation-related, hemorrhage-related, and hypoxia-related pathologic placenta index scores. Cox regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for mortality adjusting for covariates.
RESULTS: Thirty-nine percent of women died with mean (standard deviation, SD) time to death of 39 (12) years. Mean (SD) placental weight and birthweight were 436 g (98) and 3156 g (566), respectively. Placenta-to-birthweight ratio was associated with all-cause mortality (adjusted HR 1.03: 1.01, 1.05 per SD in ratio). In cause-specific analyses, it was significantly associated with respiratory (HR 1.06), dementia (HR: 1.10) and liver (HR 1.04) related deaths. CVD, cancer, diabetes and kidney related deaths also tended to increase, whereas infection related deaths did not (HR 0.94; 0.83, 1.06). Placental measures of thickness, diameters, and histopathological measures grouped by inflammatory, hemorrhagic, or hypoxic etiology were not associated with mortality.
DISCUSSION: Placental weight in relation to birthweight was associated with long-term maternal mortality but other histopathologic or morphologic features were not.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
|---|---|
| Enthalten in: |
Placenta - 117(2022) vom: 22. Jan., Seite 194-199 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yeung, E H [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Birthweight |
|---|
| Anmerkungen: |
Date Completed 10.03.2022 Date Revised 02.01.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.placenta.2021.12.014 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM33465498X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM33465498X | ||
| 003 | DE-627 | ||
| 005 | 20231225224151.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.placenta.2021.12.014 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1115.xml |
| 035 | |a (DE-627)NLM33465498X | ||
| 035 | |a (NLM)34929460 | ||
| 035 | |a (PII)S0143-4004(21)00663-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yeung, E H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Placental characteristics and risks of maternal mortality 50 years after delivery |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 10.03.2022 | ||
| 500 | |a Date Revised 02.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier Ltd. | ||
| 520 | |a INTRODUCTION: Adverse pregnancy outcomes such as preterm delivery and preeclampsia are associated with a higher maternal risk for subsequent cardiovascular disease (CVD) and all-cause mortality. While such pregnancy conditions are related to abnormal placentation, little research has investigated whether pathologic placental measures could serve as a risk factor for future CVD mortality in mothers | ||
| 520 | |a METHODS: Longitudinal study of 33,336 women from the Collaborative Perinatal Project (CPP; 1959-1966) linked to mortality information through December 2016. Pathologists took extensive morphological and histopathological measures. Apart from assessing associations with morphological features, we derived an overall composite score and specific inflammation-related, hemorrhage-related, and hypoxia-related pathologic placenta index scores. Cox regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for mortality adjusting for covariates | ||
| 520 | |a RESULTS: Thirty-nine percent of women died with mean (standard deviation, SD) time to death of 39 (12) years. Mean (SD) placental weight and birthweight were 436 g (98) and 3156 g (566), respectively. Placenta-to-birthweight ratio was associated with all-cause mortality (adjusted HR 1.03: 1.01, 1.05 per SD in ratio). In cause-specific analyses, it was significantly associated with respiratory (HR 1.06), dementia (HR: 1.10) and liver (HR 1.04) related deaths. CVD, cancer, diabetes and kidney related deaths also tended to increase, whereas infection related deaths did not (HR 0.94; 0.83, 1.06). Placental measures of thickness, diameters, and histopathological measures grouped by inflammatory, hemorrhagic, or hypoxic etiology were not associated with mortality | ||
| 520 | |a DISCUSSION: Placental weight in relation to birthweight was associated with long-term maternal mortality but other histopathologic or morphologic features were not | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Birthweight | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Placental diameter | |
| 650 | 4 | |a Placental histopathology | |
| 650 | 4 | |a Placental weight | |
| 700 | 1 | |a Saha, A |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, C |e verfasserin |4 aut | |
| 700 | 1 | |a Trinh, M H |e verfasserin |4 aut | |
| 700 | 1 | |a Hinkle, S N |e verfasserin |4 aut | |
| 700 | 1 | |a Pollack, A Z |e verfasserin |4 aut | |
| 700 | 1 | |a Grantz, K L |e verfasserin |4 aut | |
| 700 | 1 | |a Mills, J L |e verfasserin |4 aut | |
| 700 | 1 | |a Mumford, S L |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, C |e verfasserin |4 aut | |
| 700 | 1 | |a Robinson, S L |e verfasserin |4 aut | |
| 700 | 1 | |a Gillman, M W |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, J |e verfasserin |4 aut | |
| 700 | 1 | |a Mendola, P |e verfasserin |4 aut | |
| 700 | 1 | |a Sundaram, R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Placenta |d 1987 |g 117(2022) vom: 22. Jan., Seite 194-199 |w (DE-627)NLM012770787 |x 1532-3102 |7 nnns |
| 773 | 1 | 8 | |g volume:117 |g year:2022 |g day:22 |g month:01 |g pages:194-199 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.placenta.2021.12.014 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 117 |j 2022 |b 22 |c 01 |h 194-199 | ||