Risk factors for mortality in patients over 65 years old hospitalized by COVID-19
Copyright © 2021 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved..
BACKGROUND AND OBJECTIVE: COVID-19 is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has caused a global pandemic that we are currently suffering from.
OBJECTIVE: to identify factors associated with the death of patients aged 65 years or older hospitalized for COVID-19.
MATERIALS AND METHODS: Retrospective cohort study. We included patients aged 65 years or older who were hospitalized for COVID-19 and dead o discharged between March 5 and 25, 2020. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death.
RESULTS: 277 patients were included in this study. The bivariate analysis showed significant differences (p<0.05) between survivors and non survivors: age, increased dependence and comorbidity, history of ischemic heart disease, renal failure and non-hematological neoplasms, heart failure during admission, leukocytosis, elevated creatinine, PCR, GOT and troponin Ic values, lymphopenia, and decreased blood pH and SatO2. Multivariate logistic regression revealed that age ≥65 years (OR: 4.23 (95% CI: 1.43-12.52; p=0.009), lymphopenia <1000/μL (OR: 2.36 (95% CI: 1.07-5.20; p=0.033), creatinine>1.2mg/dL (OR: 3.08 (95% CI: 1.37-6.92; p=0.006), SatO2 <90% (OR: 2.29 (95% CI: 1.01-5.21; p=0.049) and troponin Ic>11ng/mL (OR: 2.32 (95% CI: 1.04-5.16; p=0.040) were independently associated with higher hospital mortality.
CONCLUSIONS: Older age, lymphopenia, SatO2 <90%, elevated creatinine and troponin Ic values were independently associated with higher mortality in hospitalized patients with COVID-19, these factors could help clinicians to identify patients with poor prognosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Revista espanola de geriatria y gerontologia - 57(2022), 1 vom: 24. Jan., Seite 6-12 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Factores de riesgo de mortalidad en pacientes mayores de 65 años hospitalizados por COVID-19 |
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| Beteiligte Personen: |
Fernández Ibáñez, José Manuel [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Completed 31.01.2022 Date Revised 31.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.regg.2021.09.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334602882 |
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| 100 | 1 | |a Fernández Ibáñez, José Manuel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Risk factors for mortality in patients over 65 years old hospitalized by COVID-19 |
| 246 | 3 | 3 | |a Factores de riesgo de mortalidad en pacientes mayores de 65 años hospitalizados por COVID-19 |
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| 500 | |a Date Revised 31.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a BACKGROUND AND OBJECTIVE: COVID-19 is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has caused a global pandemic that we are currently suffering from | ||
| 520 | |a OBJECTIVE: to identify factors associated with the death of patients aged 65 years or older hospitalized for COVID-19 | ||
| 520 | |a MATERIALS AND METHODS: Retrospective cohort study. We included patients aged 65 years or older who were hospitalized for COVID-19 and dead o discharged between March 5 and 25, 2020. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death | ||
| 520 | |a RESULTS: 277 patients were included in this study. The bivariate analysis showed significant differences (p<0.05) between survivors and non survivors: age, increased dependence and comorbidity, history of ischemic heart disease, renal failure and non-hematological neoplasms, heart failure during admission, leukocytosis, elevated creatinine, PCR, GOT and troponin Ic values, lymphopenia, and decreased blood pH and SatO2. Multivariate logistic regression revealed that age ≥65 years (OR: 4.23 (95% CI: 1.43-12.52; p=0.009), lymphopenia <1000/μL (OR: 2.36 (95% CI: 1.07-5.20; p=0.033), creatinine>1.2mg/dL (OR: 3.08 (95% CI: 1.37-6.92; p=0.006), SatO2 <90% (OR: 2.29 (95% CI: 1.01-5.21; p=0.049) and troponin Ic>11ng/mL (OR: 2.32 (95% CI: 1.04-5.16; p=0.040) were independently associated with higher hospital mortality | ||
| 520 | |a CONCLUSIONS: Older age, lymphopenia, SatO2 <90%, elevated creatinine and troponin Ic values were independently associated with higher mortality in hospitalized patients with COVID-19, these factors could help clinicians to identify patients with poor prognosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Edad avanzada | |
| 650 | 4 | |a Factores de riesgo | |
| 650 | 4 | |a Hospital mortality | |
| 650 | 4 | |a Hospitalized patients | |
| 650 | 4 | |a Mortalidad hospitalaria | |
| 650 | 4 | |a Older age | |
| 650 | 4 | |a Pacientes hospitalizados | |
| 650 | 4 | |a Risk factors | |
| 700 | 1 | |a Morales Ballesteros, María Del Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Galindo Andúgar, María Ángeles |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández Anguita, Manuel José |e verfasserin |4 aut | |
| 700 | 1 | |a Arias Arias, Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Barberá-Farré, José Ramón |e verfasserin |4 aut | |
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