Fabrication of moxifloxacin HCl-loaded biodegradable chitosan nanoparticles for potential antibacterial and accelerated cutaneous wound healing efficacy
AIM: This work aims to formulate topical hybrid gel containing chitosan-coated moxifloxacin (MXF) HCl nanoparticles (NPs) with enhanced antibacterial and healing activity.
METHODS: MXF HCl NPs prepared by the ionic gelation method were loaded onto a hybrid chitosan carbomer gel. Size analysis of the prepared NPs was performed using SEM and Zeta-sizer. Further characterisation was done using Fourier transforms infra-red spectroscopy (FTIR), X-ray diffraction (XRD), and Thermogravimetric analysis (TGA). Prepared gel was evaluated for its in vitro drug release, biocompatibility, antibacterial activity, and stability studies under storage conditions. In-vivo wound healing was measured by observing percentage reduction in wound.
RESULTS: NPs have 359 ± 79 nm mean particle size, 31.01 mV zeta potential with 0.008 polydispersity index (PD1), 63.5% drug entrapment and 83 ± 3.5% drug release at pH 5.5. Hybrid chitosan carbomer gel showed good biocompatibility, antibacterial, in-vivo wound healing properties and stable properties.
CONCLUSIONS: NP-loaded hybrid gel can be an effective treatment for acute and challenged topical wounds.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
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| Enthalten in: |
Journal of microencapsulation - 39(2022), 1 vom: 29. Jan., Seite 37-48 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hameed, Misbah [VerfasserIn] |
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| Links: |
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| Themen: |
9012-76-4 |
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| Anmerkungen: |
Date Completed 15.02.2022 Date Revised 01.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2021.2019332 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334551706 |
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| 245 | 1 | 0 | |a Fabrication of moxifloxacin HCl-loaded biodegradable chitosan nanoparticles for potential antibacterial and accelerated cutaneous wound healing efficacy |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 01.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: This work aims to formulate topical hybrid gel containing chitosan-coated moxifloxacin (MXF) HCl nanoparticles (NPs) with enhanced antibacterial and healing activity | ||
| 520 | |a METHODS: MXF HCl NPs prepared by the ionic gelation method were loaded onto a hybrid chitosan carbomer gel. Size analysis of the prepared NPs was performed using SEM and Zeta-sizer. Further characterisation was done using Fourier transforms infra-red spectroscopy (FTIR), X-ray diffraction (XRD), and Thermogravimetric analysis (TGA). Prepared gel was evaluated for its in vitro drug release, biocompatibility, antibacterial activity, and stability studies under storage conditions. In-vivo wound healing was measured by observing percentage reduction in wound | ||
| 520 | |a RESULTS: NPs have 359 ± 79 nm mean particle size, 31.01 mV zeta potential with 0.008 polydispersity index (PD1), 63.5% drug entrapment and 83 ± 3.5% drug release at pH 5.5. Hybrid chitosan carbomer gel showed good biocompatibility, antibacterial, in-vivo wound healing properties and stable properties | ||
| 520 | |a CONCLUSIONS: NP-loaded hybrid gel can be an effective treatment for acute and challenged topical wounds | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Moxifloxacin HCl | |
| 650 | 4 | |a antibacterial | |
| 650 | 4 | |a chitosan | |
| 650 | 4 | |a nanoparticles | |
| 650 | 4 | |a wound healing | |
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| 650 | 7 | |a Moxifloxacin |2 NLM | |
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| 700 | 1 | |a Rasul, Akhtar |e verfasserin |4 aut | |
| 700 | 1 | |a Latif, Sumera |e verfasserin |4 aut | |
| 700 | 1 | |a Rasool, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Abbas, Ghulam |e verfasserin |4 aut | |
| 700 | 1 | |a Siddique, Muhammad Irfan |e verfasserin |4 aut | |
| 700 | 1 | |a Waqas, Muhammad Khurram |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Ikram Ullah |e verfasserin |4 aut | |
| 700 | 1 | |a Yousaf, Abid Mehmood |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Pervaiz Akhtar |e verfasserin |4 aut | |
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