Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes
Copyright © 2021 Kuwashiro, Tanabe, Hayashi, Mizoguchi, Mori, Jinnouchi, Yasaka and Okada..
Background: There is high demand for blood biomarkers that reflect the therapeutic response or predict the outcomes of patients with acute ischemic stroke (AIS); however, few biomarkers have been evidentially verified to date. This study evaluated two proteins, oxidized albumin (OxHSA) and cartilage acidic protein-1 (CRTAC1), as potential prognostic markers of AIS. Methods: The ratio of OxHSA to normal albumin (%OxHSA) and the level of CRTAC1 in the sera of 74 AIS patients were analyzed on admission (day 0), and at 1 and 7 days after admission. AIS patients were divided into two groups according to their modified Rankin Scale (mRS) at 3 months after discharge: the low-mRS (mRS < 2) group included 48 patients and the high-mRS (mRS ≥ 2) group included 26 patients. The differences in %OxHSA and CRTAC1 between the two groups on days 0, 1, and 7 were evaluated. Results: The mean %OxHSA values of the high-mRS group on days 0, 1, and 7 were significantly higher than those of the low-mRS group (p < 0.05). The CRTAC1 levels continuously increased from day 0 to day 7, and those of the high-mRS group were significantly higher than those of the low-mRS group on day 7 (p < 0.05). Conclusions: These results suggest that higher %OxHSA and CRTAC1 are associated with poor outcomes in AIS patients. An index that combines %OxHSA and CRTAC1 can accurately predict the outcomes of AIS patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in neurology - 12(2021) vom: 25., Seite 686555 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kuwashiro, Takahiro [VerfasserIn] |
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| Links: |
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| Themen: |
Acute ischemic stroke |
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| Anmerkungen: |
Date Revised 18.12.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fneur.2021.686555 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334532086 |
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| 100 | 1 | |a Kuwashiro, Takahiro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes |
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| 500 | |a Date Revised 18.12.2021 | ||
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2021 Kuwashiro, Tanabe, Hayashi, Mizoguchi, Mori, Jinnouchi, Yasaka and Okada. | ||
| 520 | |a Background: There is high demand for blood biomarkers that reflect the therapeutic response or predict the outcomes of patients with acute ischemic stroke (AIS); however, few biomarkers have been evidentially verified to date. This study evaluated two proteins, oxidized albumin (OxHSA) and cartilage acidic protein-1 (CRTAC1), as potential prognostic markers of AIS. Methods: The ratio of OxHSA to normal albumin (%OxHSA) and the level of CRTAC1 in the sera of 74 AIS patients were analyzed on admission (day 0), and at 1 and 7 days after admission. AIS patients were divided into two groups according to their modified Rankin Scale (mRS) at 3 months after discharge: the low-mRS (mRS < 2) group included 48 patients and the high-mRS (mRS ≥ 2) group included 26 patients. The differences in %OxHSA and CRTAC1 between the two groups on days 0, 1, and 7 were evaluated. Results: The mean %OxHSA values of the high-mRS group on days 0, 1, and 7 were significantly higher than those of the low-mRS group (p < 0.05). The CRTAC1 levels continuously increased from day 0 to day 7, and those of the high-mRS group were significantly higher than those of the low-mRS group on day 7 (p < 0.05). Conclusions: These results suggest that higher %OxHSA and CRTAC1 are associated with poor outcomes in AIS patients. An index that combines %OxHSA and CRTAC1 can accurately predict the outcomes of AIS patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a LC-MS/MS | |
| 650 | 4 | |a acute ischemic stroke | |
| 650 | 4 | |a biomarker (BM) | |
| 650 | 4 | |a cartilage acidic protein-1 | |
| 650 | 4 | |a mass spectrometry | |
| 650 | 4 | |a oxidative stress | |
| 650 | 4 | |a oxidized albumin | |
| 700 | 1 | |a Tanabe, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Chihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Mizoguchi, Tadataka |e verfasserin |4 aut | |
| 700 | 1 | |a Mori, Kota |e verfasserin |4 aut | |
| 700 | 1 | |a Jinnouchi, Juro |e verfasserin |4 aut | |
| 700 | 1 | |a Yasaka, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Yasushi |e verfasserin |4 aut | |
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