Gastrointestinal angiodysplasia in heart failure and during CF LVAD support
Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved..
Angiodysplasias (AGD) are common sites of bleeding in the gastrointestinal (GI) tract after Continuous Flow Left Ventricular Assist Device (CF-LVAD) implantation. We sought to investigate whether AGDs are formed as a result of LVAD physiology or preexist as a consequence of heart failure. Thirty-six subjects with HF reduced EF (HFrEF) underwent video capsule endoscopy (VCE) to assess for the presence of AGD. Fifty-three subjects without HF who underwent VCE for a nonbleeding indication formed a control group. The prevalence of AGD was significantly higher in the HFrEF compared to the non-HF controls (50% vs 13%, p = 0.0002). This association persisted after controlling for age and comorbidities. Within the HFrEF cohort, higher Ang2, NT-proBNP and BUN were associated with the presence of AGD. AGD in the GI tract are associated with HFrEF. This is the first description of a new pathology associated with HFrEF and adds to our understanding of CF LVAD associated GI bleeding.
| Errataetall: |
CommentIn: J Heart Lung Transplant. 2022 Nov;41(11):1655-1656. - PMID 36096898 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 41(2022), 2 vom: 15. Feb., Seite 129-132 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Patel, Snehal R [VerfasserIn] |
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| Anmerkungen: |
Date Completed 09.03.2022 Date Revised 07.11.2022 published: Print-Electronic CommentIn: J Heart Lung Transplant. 2022 Nov;41(11):1655-1656. - PMID 36096898 Citation Status MEDLINE |
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| doi: |
10.1016/j.healun.2021.11.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334479010 |
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| 500 | |a CommentIn: J Heart Lung Transplant. 2022 Nov;41(11):1655-1656. - PMID 36096898 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Angiodysplasias (AGD) are common sites of bleeding in the gastrointestinal (GI) tract after Continuous Flow Left Ventricular Assist Device (CF-LVAD) implantation. We sought to investigate whether AGDs are formed as a result of LVAD physiology or preexist as a consequence of heart failure. Thirty-six subjects with HF reduced EF (HFrEF) underwent video capsule endoscopy (VCE) to assess for the presence of AGD. Fifty-three subjects without HF who underwent VCE for a nonbleeding indication formed a control group. The prevalence of AGD was significantly higher in the HFrEF compared to the non-HF controls (50% vs 13%, p = 0.0002). This association persisted after controlling for age and comorbidities. Within the HFrEF cohort, higher Ang2, NT-proBNP and BUN were associated with the presence of AGD. AGD in the GI tract are associated with HFrEF. This is the first description of a new pathology associated with HFrEF and adds to our understanding of CF LVAD associated GI bleeding | ||
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| 700 | 1 | |a Vukelic, Sasha |e verfasserin |4 aut | |
| 700 | 1 | |a Chinnadurai, Thiru |e verfasserin |4 aut | |
| 700 | 1 | |a Madan, Shivank |e verfasserin |4 aut | |
| 700 | 1 | |a Sibinga, Nicholas |e verfasserin |4 aut | |
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| 700 | 1 | |a Saeed, Omar |e verfasserin |4 aut | |
| 700 | 1 | |a Goldstein, Daniel J |e verfasserin |4 aut | |
| 700 | 1 | |a Jorde, Ulrich P |e verfasserin |4 aut | |
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