Clinical and epidemiological characterization in the follow-up of newborns with COVID-19 : a descriptive study
INTRODUCTION: COVID-19 disease affects newborns, but its middle and long-term effects are still unclear.
OBJECTIVE: To describe the clinical and epidemiological characteristics and follow-up of newborns infected with SARS-CoV-2.
METHODS: An observational and descriptive study. We included newborns with SARS-CoV-2 positive RT-PCR born from SARS-CoV-2 seropositive mothers. Delivery and newborn care were provided at the 'Instituto Nacional Materno Perinatal' from Peru between June 1 and September 30, 2020. Perinatal information was collected from medical records. Remote follow-up and face-to-face evaluations gathered epidemiological and clinical information, in addition to serological and RT-PCR tests for SARS-CoV-2. Descriptive statistics were used for analysis.
RESULTS: During the study period, 4733 neonates were born at the institution. We found that 1488 (31.4%) were born from seropositive for SARS-CoV-2 mothers. Finally, we included the 34 (2.3%) newborns with positive RT-PCR for SARS-CoV-2. Regarding the included newborns, 29.4% were delivered by cesarean section, 26.5% had low birth weight, 11.8% were preterm, 26.5% were hospitalized, and one died. Twenty-eight had a remote follow-up, and 18 also had a face-to-face follow-up. A total of 64.3% were exclusively breastfed, 28.6% were mixed breastfed, and 7.1% used a substitute formula. The face-to-face evaluation was performed between one and four months of chronological age. We found that 100% had negative control RT-PCR test for COVID-19, 38.9% had a negative serological test (IgM, IgG), and 61.1% positive IgG.
CONCLUSIONS: Neonatal SARS-CoV-2 infection is rare, and most infected infants are asymptomatic. Vaginal delivery, breastfeeding, and joint isolation did not related with complications during hospital care. Infants under remote and in-person follow-up showed favorable clinical evolution during the study period.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Medwave - 21(2021), 11 vom: 15. Dez., Seite e8500 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Caracterización clínica y epidemiológica en el seguimiento de recién nacidos con COVID-19: estudio descriptivo |
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| Beteiligte Personen: |
Dávila-Aliaga, Carmen [VerfasserIn] |
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| Links: |
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| Themen: |
Coronavirus infection |
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| Anmerkungen: |
Date Completed 17.12.2021 Date Revised 29.04.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.5867/medwave.2021.11.002141 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334469724 |
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| 245 | 1 | 0 | |a Clinical and epidemiological characterization in the follow-up of newborns with COVID-19 |b a descriptive study |
| 246 | 3 | 3 | |a Caracterización clínica y epidemiológica en el seguimiento de recién nacidos con COVID-19: estudio descriptivo |
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| 500 | |a Date Completed 17.12.2021 | ||
| 500 | |a Date Revised 29.04.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: COVID-19 disease affects newborns, but its middle and long-term effects are still unclear | ||
| 520 | |a OBJECTIVE: To describe the clinical and epidemiological characteristics and follow-up of newborns infected with SARS-CoV-2 | ||
| 520 | |a METHODS: An observational and descriptive study. We included newborns with SARS-CoV-2 positive RT-PCR born from SARS-CoV-2 seropositive mothers. Delivery and newborn care were provided at the 'Instituto Nacional Materno Perinatal' from Peru between June 1 and September 30, 2020. Perinatal information was collected from medical records. Remote follow-up and face-to-face evaluations gathered epidemiological and clinical information, in addition to serological and RT-PCR tests for SARS-CoV-2. Descriptive statistics were used for analysis | ||
| 520 | |a RESULTS: During the study period, 4733 neonates were born at the institution. We found that 1488 (31.4%) were born from seropositive for SARS-CoV-2 mothers. Finally, we included the 34 (2.3%) newborns with positive RT-PCR for SARS-CoV-2. Regarding the included newborns, 29.4% were delivered by cesarean section, 26.5% had low birth weight, 11.8% were preterm, 26.5% were hospitalized, and one died. Twenty-eight had a remote follow-up, and 18 also had a face-to-face follow-up. A total of 64.3% were exclusively breastfed, 28.6% were mixed breastfed, and 7.1% used a substitute formula. The face-to-face evaluation was performed between one and four months of chronological age. We found that 100% had negative control RT-PCR test for COVID-19, 38.9% had a negative serological test (IgM, IgG), and 61.1% positive IgG | ||
| 520 | |a CONCLUSIONS: Neonatal SARS-CoV-2 infection is rare, and most infected infants are asymptomatic. Vaginal delivery, breastfeeding, and joint isolation did not related with complications during hospital care. Infants under remote and in-person follow-up showed favorable clinical evolution during the study period | ||
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