Volumetric evaluation of 99mTc-pyrophosphate SPECT/CT for transthyretin cardiac amyloidosis : Methodology and correlation with cardiac functional parameters
© 2021. The Author(s)..
BACKGROUND: Volumetric evaluation of 99mTechnetium-pyrophosphate (99mTc-PYP) SPECT/CT is a useful method for assessing transthyretin cardiac amyloidosis (ATTR-CA). We investigated the methodology and assessed its relationship with conventional parameters.
METHODS AND RESULTS: We retrospectively evaluated 99mTc-PYP SPECT/CT scans of 25 patients who underwent endomyocardial biopsy and/or gene testing. Fourteen (56%) patients were diagnosed with ATTR-CA. SPECT/CT images were acquired at 3 hours after injection. Total volumes of the myocardial regions where uptakes were > 1.2 and 1.4 × aortic blood pool SUVmax were evaluated and defined as cardiac pyrophosphate volume (CPV1.2 and CPV1.4). The heart-to-contralateral lung (H/CL) ratio and myocardial SUVmax were also calculated. CPV1.2 achieved the highest sensitivity and specificity in diagnosing ATTR-CA. In patients diagnosed with ATTR-CA (n = 14), CPV1.2 negatively correlated with left ventricular ejection fraction and positively correlated with left ventricular posterior wall thickness and QRS duration. The correlation was stronger in CPV1.2 than in the H/CL ratio and SUVmax.
CONCLUSION: Volumetric evaluation of 99mTc-PYP SPECT/CT may be superior to the H/CL ratio and SUVmax in assessing the disease burden of ATTR-CA. Larger studies are warranted to clarify whether volumetric measurement can assess prognosis and disease progression.
Errataetall: |
CommentIn: J Nucl Cardiol. 2022 Dec;29(6):3111-3114. - PMID 34921352 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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Enthalten in: |
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology - 29(2022), 6 vom: 25. Dez., Seite 3102-3110 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Watanabe, Satoru [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 13.01.2023 Date Revised 30.01.2024 published: Print-Electronic CommentIn: J Nucl Cardiol. 2022 Dec;29(6):3111-3114. - PMID 34921352 Citation Status MEDLINE |
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doi: |
10.1007/s12350-021-02857-7 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM334438993 |
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520 | |a © 2021. The Author(s). | ||
520 | |a BACKGROUND: Volumetric evaluation of 99mTechnetium-pyrophosphate (99mTc-PYP) SPECT/CT is a useful method for assessing transthyretin cardiac amyloidosis (ATTR-CA). We investigated the methodology and assessed its relationship with conventional parameters | ||
520 | |a METHODS AND RESULTS: We retrospectively evaluated 99mTc-PYP SPECT/CT scans of 25 patients who underwent endomyocardial biopsy and/or gene testing. Fourteen (56%) patients were diagnosed with ATTR-CA. SPECT/CT images were acquired at 3 hours after injection. Total volumes of the myocardial regions where uptakes were > 1.2 and 1.4 × aortic blood pool SUVmax were evaluated and defined as cardiac pyrophosphate volume (CPV1.2 and CPV1.4). The heart-to-contralateral lung (H/CL) ratio and myocardial SUVmax were also calculated. CPV1.2 achieved the highest sensitivity and specificity in diagnosing ATTR-CA. In patients diagnosed with ATTR-CA (n = 14), CPV1.2 negatively correlated with left ventricular ejection fraction and positively correlated with left ventricular posterior wall thickness and QRS duration. The correlation was stronger in CPV1.2 than in the H/CL ratio and SUVmax | ||
520 | |a CONCLUSION: Volumetric evaluation of 99mTc-PYP SPECT/CT may be superior to the H/CL ratio and SUVmax in assessing the disease burden of ATTR-CA. Larger studies are warranted to clarify whether volumetric measurement can assess prognosis and disease progression | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Amyloid heart disease | |
650 | 4 | |a Cardiomyopathy | |
650 | 4 | |a Hybrid imaging | |
650 | 4 | |a Image analysis | |
650 | 4 | |a SPECT | |
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700 | 1 | |a Wakabayashi, Hiroshi |e verfasserin |4 aut | |
700 | 1 | |a Yoneyama, Hiroto |e verfasserin |4 aut | |
700 | 1 | |a Yoshida, Shohei |e verfasserin |4 aut | |
700 | 1 | |a Komatsu, Junji |e verfasserin |4 aut | |
700 | 1 | |a Konishi, Takahiro |e verfasserin |4 aut | |
700 | 1 | |a Inaki, Anri |e verfasserin |4 aut | |
700 | 1 | |a Kinuya, Seigo |e verfasserin |4 aut | |
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