Controlling the Burden of COVID-19 by Manipulating Host Metabolism
The coronavirus disease 2019 (COVID-19) pandemic caused by the coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause global health problems, but its impact would be minimized if the many effective vaccines that have been developed were available and in widespread use by all societies. This ideal situation is not occurring so other means of controlling COVID-19 are needed. In this short review, we make the case that manipulating host metabolic pathways could be a therapeutic approach worth exploring. The rationale for such an approach comes from the fact that viruses cause metabolic changes in cells they infect, effective host defense mechanisms against viruses requires the activity of one or more metabolic pathways, and that hosts with metabolic defects such as diabetes are more susceptible to severe consequences after COVID-19. We describe the types of approaches that could be used to redirect various aspects of host metabolism and the success that some of these maneuvers have had at controlling other virus infections. Manipulating metabolic activities to control the outcome of COVID-19 has to date received minimal attention. Manipulating host metabolism will never replace vaccines to control COVID-19 but could be used as an adjunct therapy to the extent of ongoing infection.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
---|---|
Enthalten in: |
Viral immunology - 35(2022), 1 vom: 01. Jan., Seite 24-32 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Miller, Logan [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 21.02.2022 Date Revised 02.02.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1089/vim.2021.0150 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM334418348 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM334418348 | ||
003 | DE-627 | ||
005 | 20231225223647.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1089/vim.2021.0150 |2 doi | |
028 | 5 | 2 | |a pubmed24n1114.xml |
035 | |a (DE-627)NLM334418348 | ||
035 | |a (NLM)34905407 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Miller, Logan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Controlling the Burden of COVID-19 by Manipulating Host Metabolism |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.02.2022 | ||
500 | |a Date Revised 02.02.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a The coronavirus disease 2019 (COVID-19) pandemic caused by the coronavirus-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause global health problems, but its impact would be minimized if the many effective vaccines that have been developed were available and in widespread use by all societies. This ideal situation is not occurring so other means of controlling COVID-19 are needed. In this short review, we make the case that manipulating host metabolic pathways could be a therapeutic approach worth exploring. The rationale for such an approach comes from the fact that viruses cause metabolic changes in cells they infect, effective host defense mechanisms against viruses requires the activity of one or more metabolic pathways, and that hosts with metabolic defects such as diabetes are more susceptible to severe consequences after COVID-19. We describe the types of approaches that could be used to redirect various aspects of host metabolism and the success that some of these maneuvers have had at controlling other virus infections. Manipulating metabolic activities to control the outcome of COVID-19 has to date received minimal attention. Manipulating host metabolism will never replace vaccines to control COVID-19 but could be used as an adjunct therapy to the extent of ongoing infection | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Review | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a consequence | |
650 | 4 | |a immunity | |
650 | 4 | |a long COVID | |
650 | 4 | |a metabolism | |
650 | 4 | |a outcome | |
700 | 1 | |a Berber, Engin |e verfasserin |4 aut | |
700 | 1 | |a Sumbria, Deepak |e verfasserin |4 aut | |
700 | 1 | |a Rouse, Barry T |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Viral immunology |d 1993 |g 35(2022), 1 vom: 01. Jan., Seite 24-32 |w (DE-627)NLM012623369 |x 1557-8976 |7 nnns |
773 | 1 | 8 | |g volume:35 |g year:2022 |g number:1 |g day:01 |g month:01 |g pages:24-32 |
856 | 4 | 0 | |u http://dx.doi.org/10.1089/vim.2021.0150 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 35 |j 2022 |e 1 |b 01 |c 01 |h 24-32 |