Experimental asynchrony to study self-inflicted lung injury
Copyright © 2021 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved..
Patient self-inflicted lung injury may be associated with worse clinical outcomes and higher mortality. Patient-ventilator asynchrony is associated with increased ventilator days and mortality, and it has been hypothesised as one of the important mechanisms leading to patient self-inflicted lung injury. However, given the observational nature of the key studies in the field so far, the hypothesis that patient-ventilator asynchrony causes patient self-inflicted lung injury has not been supported by evidence yet. Wittenstein and colleagues present a novel approach that enables controlling patient-ventilator asynchrony in a pig model of acute lung injury, to investigate the patient-ventilator asynchrony and patient self-inflicted lung injury causality. Their results suggest that increased patient-ventilator asynchrony associated with poor clinical outcomes reported in observational trials could be a marker, rather than a cause of patient self-inflicted lung injury. These findings on their own are not sufficient to justify a greater tolerance of patient-ventilator asynchrony amongst clinicians, a change for which further experimental work and clinical evidence is needed.
| Errataetall: |
CommentOn: Br J Anaesth. 2023 Jan;130(1):e169-e178. - PMID 34895719 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
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| Enthalten in: |
British journal of anaesthesia - 130(2023), 1 vom: 15. Jan., Seite e44-e46 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cronin, John N [VerfasserIn] |
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Comment |
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| Anmerkungen: |
Date Completed 03.01.2023 Date Revised 11.01.2023 published: Print-Electronic CommentOn: Br J Anaesth. 2023 Jan;130(1):e169-e178. - PMID 34895719 Citation Status MEDLINE |
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| doi: |
10.1016/j.bja.2021.11.020 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Patient self-inflicted lung injury may be associated with worse clinical outcomes and higher mortality. Patient-ventilator asynchrony is associated with increased ventilator days and mortality, and it has been hypothesised as one of the important mechanisms leading to patient self-inflicted lung injury. However, given the observational nature of the key studies in the field so far, the hypothesis that patient-ventilator asynchrony causes patient self-inflicted lung injury has not been supported by evidence yet. Wittenstein and colleagues present a novel approach that enables controlling patient-ventilator asynchrony in a pig model of acute lung injury, to investigate the patient-ventilator asynchrony and patient self-inflicted lung injury causality. Their results suggest that increased patient-ventilator asynchrony associated with poor clinical outcomes reported in observational trials could be a marker, rather than a cause of patient self-inflicted lung injury. These findings on their own are not sufficient to justify a greater tolerance of patient-ventilator asynchrony amongst clinicians, a change for which further experimental work and clinical evidence is needed | ||
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