Anthraquinones with potential antiproliferative activities from the fruits of Morinda citrifolia
The phytochemical investigation on the fruits of Morinda citrifolia led to the isolation and characterization of a new anthraquinone, moricitrifone (1), along with seven known anthraquinones (2-8). The chemical structure of 1 was elucidated by extensive spectral analyses. The known compounds (2-8) were identified by comparing their spectral data with those reported in the literature. The antiproliferative activities of all isolated anthraquinones (1-8) against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 were evaluated in vitro. Compounds 1-8 exhibited remarkable antiproliferative activities with IC50 values ranging from 0.26 ± 0.05 to 16.58 ± 0.18 μM, which were comparable to those of doxorubicin.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Natural product research - 37(2023), 9 vom: 13. Mai, Seite 1456-1462 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shen, Zhang-Yang [VerfasserIn] |
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| Links: |
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| Themen: |
Anthraquinones |
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| Anmerkungen: |
Date Completed 17.04.2023 Date Revised 17.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14786419.2021.2012670 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334313872 |
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| 520 | |a The phytochemical investigation on the fruits of Morinda citrifolia led to the isolation and characterization of a new anthraquinone, moricitrifone (1), along with seven known anthraquinones (2-8). The chemical structure of 1 was elucidated by extensive spectral analyses. The known compounds (2-8) were identified by comparing their spectral data with those reported in the literature. The antiproliferative activities of all isolated anthraquinones (1-8) against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 were evaluated in vitro. Compounds 1-8 exhibited remarkable antiproliferative activities with IC50 values ranging from 0.26 ± 0.05 to 16.58 ± 0.18 μM, which were comparable to those of doxorubicin | ||
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| 700 | 1 | |a Qiao, Ze-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Zhen |e verfasserin |4 aut | |
| 700 | 1 | |a Guan, Ruo-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ze-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yan-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Guang-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Yan-Hui |e verfasserin |4 aut | |
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