Clinical burden of hemophilia in older adults : Beyond bleeding risk
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..
The prospect of hemophilia patients has dramatically improved in the last few decades with the introduction of various interventions that can effectively treat or prevent their bleeding risk. The life expectancy of patients can now reach that of the healthy population, but this has paved the way for several previously unrecognized morbidities to manifest in older adults with hemophilia. Such clinical complications are attributed to suboptimal management or poor access to effective therapy during childhood as well as chronicity and prolonged exposure to the underlying pathophysiology of the disease and its treatment. Complications common in the aging population are also becoming increasingly relevant in this vulnerable patient subgroup. In this review, we highlight peculiarities of such morbidities including chronic viral infections and liver disease, debilitating joint impairment and bone disease, cardiovascular and chronic kidney disease, and cancers. We also reflect on topics of special interest in adulthood such as sexuality.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Blood reviews - 53(2022) vom: 21. Mai, Seite 100912 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hodroj, Mohammad Hassan [VerfasserIn] |
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| Links: |
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| Themen: |
Aging |
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| Anmerkungen: |
Date Completed 19.04.2022 Date Revised 09.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.blre.2021.100912 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The prospect of hemophilia patients has dramatically improved in the last few decades with the introduction of various interventions that can effectively treat or prevent their bleeding risk. The life expectancy of patients can now reach that of the healthy population, but this has paved the way for several previously unrecognized morbidities to manifest in older adults with hemophilia. Such clinical complications are attributed to suboptimal management or poor access to effective therapy during childhood as well as chronicity and prolonged exposure to the underlying pathophysiology of the disease and its treatment. Complications common in the aging population are also becoming increasingly relevant in this vulnerable patient subgroup. In this review, we highlight peculiarities of such morbidities including chronic viral infections and liver disease, debilitating joint impairment and bone disease, cardiovascular and chronic kidney disease, and cancers. We also reflect on topics of special interest in adulthood such as sexuality | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Complications | |
| 650 | 4 | |a Hemophilia | |
| 650 | 4 | |a Management | |
| 650 | 4 | |a Morbidity | |
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| 700 | 1 | |a Al-Shamsi, Humaid O |e verfasserin |4 aut | |
| 700 | 1 | |a Samaha, Hanady |e verfasserin |4 aut | |
| 700 | 1 | |a Musallam, Khaled M |e verfasserin |4 aut | |
| 700 | 1 | |a Taher, Ali T |e verfasserin |4 aut | |
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