PrP C as a Transducer of Physiological and Pathological Signals
Copyright © 2021 Panes, Saavedra, Pineda, Escobar, Cuevas, Moraga-Cid, Fuentealba, Rivas, Rezaei and Muñoz-Montesino..
After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrP C ) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrP C in health and disease. PrP C , which is located mainly at the plasma membrane of neuronal cells attached by a glycosylphosphatidylinositol (GPI) anchor, can act as a receptor or transducer from external signaling. Although the precise role of PrP C remains elusive, a variety of functions have been proposed for this protein, namely, neuronal excitability and viability. Although many issues must be solved to clearly define the role of PrP C , its connection to the central nervous system (CNS) and to several misfolding-associated diseases makes PrP C an interesting pharmacological target. In a physiological context, several reports have proposed that PrP C modulates synaptic transmission, interacting with various proteins, namely, ion pumps, channels, and metabotropic receptors. PrP C has also been implicated in the pathophysiological cell signaling induced by β-amyloid peptide that leads to synaptic dysfunction in the context of Alzheimer's disease (AD), as a mediator of Aβ-induced cell toxicity. Additionally, it has been implicated in other proteinopathies as well. In this review, we aimed to analyze the role of PrP C as a transducer of physiological and pathological signaling.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Frontiers in molecular neuroscience - 14(2021) vom: 01., Seite 762918 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Panes, Jessica D [VerfasserIn] |
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| Links: |
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| Themen: |
Aβ |
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| Anmerkungen: |
Date Revised 11.12.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fnmol.2021.762918 |
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| 520 | |a After the discovery of prion phenomenon, the physiological role of the cellular prion protein (PrP C ) remained elusive. In the past decades, molecular and cellular analysis has shed some light regarding interactions and functions of PrP C in health and disease. PrP C , which is located mainly at the plasma membrane of neuronal cells attached by a glycosylphosphatidylinositol (GPI) anchor, can act as a receptor or transducer from external signaling. Although the precise role of PrP C remains elusive, a variety of functions have been proposed for this protein, namely, neuronal excitability and viability. Although many issues must be solved to clearly define the role of PrP C , its connection to the central nervous system (CNS) and to several misfolding-associated diseases makes PrP C an interesting pharmacological target. In a physiological context, several reports have proposed that PrP C modulates synaptic transmission, interacting with various proteins, namely, ion pumps, channels, and metabotropic receptors. PrP C has also been implicated in the pathophysiological cell signaling induced by β-amyloid peptide that leads to synaptic dysfunction in the context of Alzheimer's disease (AD), as a mediator of Aβ-induced cell toxicity. Additionally, it has been implicated in other proteinopathies as well. In this review, we aimed to analyze the role of PrP C as a transducer of physiological and pathological signaling | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 650 | 4 | |a PrP | |
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| 700 | 1 | |a Saavedra, Paulina |e verfasserin |4 aut | |
| 700 | 1 | |a Pineda, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Escobar, Kathleen |e verfasserin |4 aut | |
| 700 | 1 | |a Cuevas, Magdalena E |e verfasserin |4 aut | |
| 700 | 1 | |a Moraga-Cid, Gustavo |e verfasserin |4 aut | |
| 700 | 1 | |a Fuentealba, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Rivas, Coralia I |e verfasserin |4 aut | |
| 700 | 1 | |a Rezaei, Human |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Montesino, Carola |e verfasserin |4 aut | |
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