Direct Interstitial Decongestion in an Animal Model of Acute-on-Chronic Ischemic Heart Failure
© 2021 The Authors..
Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% ± 9%, P = 0.029) compared to controls (+46% ± 9%, P = 0.003). Device-mediated thoracic duct decompression effectively reduced EVLW. Human studies may establish device-based interstitial decongestion as a new ADHF treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
JACC. Basic to translational science - 6(2021), 11 vom: 26. Nov., Seite 872-881 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abraham, William T [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 07.12.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jacbts.2021.09.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334066719 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021 The Authors. | ||
| 520 | |a Removal of excess fluid in acute decompensated heart failure (ADHF) targets the intravascular space, whereas most fluid resides in the interstitial space. The authors evaluated an approach to interstitial decongestion using a device to enhance lymph flow. The device was deployed in sheep with induced heart failure (HF) and acute volume overload to create a low-pressure zone at the thoracic duct outlet. Treatment decreased extravascular lung water (EVLW) volume (mL/kg) (-32% ± 9%, P = 0.029) compared to controls (+46% ± 9%, P = 0.003). Device-mediated thoracic duct decompression effectively reduced EVLW. Human studies may establish device-based interstitial decongestion as a new ADHF treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ADHF, acute decompensated heart failure | |
| 650 | 4 | |a CVP, central venous pressure | |
| 650 | 4 | |a EVLW, extravascular lung water | |
| 650 | 4 | |a acute decompensated heart failure | |
| 650 | 4 | |a decongestion | |
| 650 | 4 | |a interstitial | |
| 650 | 4 | |a lymphatic | |
| 650 | 4 | |a pulmonary edema | |
| 650 | 4 | |a thoracic duct | |
| 650 | 4 | |a volume overload | |
| 700 | 1 | |a Jonas, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Dongaonkar, Ranjeet M |e verfasserin |4 aut | |
| 700 | 1 | |a Geist, Beth |e verfasserin |4 aut | |
| 700 | 1 | |a Ueyama, Yukie |e verfasserin |4 aut | |
| 700 | 1 | |a Render, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a Youngblood, Brad |e verfasserin |4 aut | |
| 700 | 1 | |a Muir, William |e verfasserin |4 aut | |
| 700 | 1 | |a Hamlin, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Del Rio, Carlos L |e verfasserin |4 aut | |
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