A study on relationship between androgenetic alopecia and cardiovascular risk using high sensitivity C-reactive protein and galectin-3 in men with early onset baldness
OBJECTIVE: In this study, the objective was to evaluate the cardiovascular and metabolic effects in men with male pattern alopecia beginning before 30 years of age.
METHODS: Total of 81 people (41 androgenetic alopecia (AGA) and 40 healthy individuals) were included in the study. Twenty-four-hour ambulatory blood pressure (ABP) measurement, high sensitive C-reactive protein (hsCRP), galectin-3 were studied. Hamilton-Norwood scale (HNS) was used to determine the AGA types of the cases.
RESULTS: The mean age in the AGA and control groups was 30.3 ± 7.5 and 30.8 ± 6.0, respectively. Twenty-four-hour ABP measurements, hsCRP, and galectin-3 were similar in both groups. There was a positive correlation between HNS grade with age, BMI, triglyceride levels and fasting blood glucose levels in individuals with AGA. Similarly, there was a positive correlation between HNS grade with daytime pulse wave velocity and night-time reflection magnitude. A significant positive correlation was determined between hsCRP with BMI and waist circumference, and between galectin-3 with BMI, waist circumference, hip circumference, HOMA-IR in individuals with AGA.
CONCLUSIONS: This study shows that AGA patients are similar to the normal population in terms of insulin resistance or metabolic syndrome components. However, hsCRP and galectin-3 appear to be associated with cardiovascular disease risk factors in individuals with AGA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 27(2022), 1 vom: 01. Feb., Seite 71-78 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sözen, Mehmet [VerfasserIn] |
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| Links: |
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| Themen: |
9007-41-4 |
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| Anmerkungen: |
Date Completed 04.04.2022 Date Revised 30.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/1354750X.2021.2013539 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333895533 |
|---|
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| 100 | 1 | |a Sözen, Mehmet |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A study on relationship between androgenetic alopecia and cardiovascular risk using high sensitivity C-reactive protein and galectin-3 in men with early onset baldness |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 04.04.2022 | ||
| 500 | |a Date Revised 30.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: In this study, the objective was to evaluate the cardiovascular and metabolic effects in men with male pattern alopecia beginning before 30 years of age | ||
| 520 | |a METHODS: Total of 81 people (41 androgenetic alopecia (AGA) and 40 healthy individuals) were included in the study. Twenty-four-hour ambulatory blood pressure (ABP) measurement, high sensitive C-reactive protein (hsCRP), galectin-3 were studied. Hamilton-Norwood scale (HNS) was used to determine the AGA types of the cases | ||
| 520 | |a RESULTS: The mean age in the AGA and control groups was 30.3 ± 7.5 and 30.8 ± 6.0, respectively. Twenty-four-hour ABP measurements, hsCRP, and galectin-3 were similar in both groups. There was a positive correlation between HNS grade with age, BMI, triglyceride levels and fasting blood glucose levels in individuals with AGA. Similarly, there was a positive correlation between HNS grade with daytime pulse wave velocity and night-time reflection magnitude. A significant positive correlation was determined between hsCRP with BMI and waist circumference, and between galectin-3 with BMI, waist circumference, hip circumference, HOMA-IR in individuals with AGA | ||
| 520 | |a CONCLUSIONS: This study shows that AGA patients are similar to the normal population in terms of insulin resistance or metabolic syndrome components. However, hsCRP and galectin-3 appear to be associated with cardiovascular disease risk factors in individuals with AGA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Androgenetic alopecia | |
| 650 | 4 | |a Hamilton-Norwood scale | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a galectin-3 | |
| 650 | 4 | |a hsCRP | |
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| 700 | 1 | |a Baldane, Süleyman |e verfasserin |4 aut | |
| 700 | 1 | |a Abusoglu, Sedat |e verfasserin |4 aut | |
| 700 | 1 | |a Kebapcılar, Levent |e verfasserin |4 aut | |
| 700 | 1 | |a Kebapcılar, Ayşegül |e verfasserin |4 aut | |
| 700 | 1 | |a Tunçez Akyürek, Fatma |e verfasserin |4 aut | |
| 700 | 1 | |a Ünlü, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a İpekci, Süleyman Hilmi |e verfasserin |4 aut | |
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