A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state
© 2021. The Author(s)..
Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release and augment rewards. However, how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive. Here we report that the ventral pallidum (VP) projection of NAc D1-MSNs (D1NAc-VP) is inhibited by rewarding stimuli and activated by aversive stimuli. In contrast to the VM projection of D1-MSN (D1NAc-VM), activation of D1NAc-VP projection induces aversion, but not reward. D1NAc-VP MSNs are distinct from the D1NAc-VM MSNs, which exhibit conventional functions of D1-MSNs. Activation of D1NAc-VP projection stimulates VM GABAergic transmission, inhibits VM DAergic neurons, and reduces DA release into the NAc. Thus, D1NAc-VP and D1NAc-VM MSNs cooperatively control NAc dopamine balance and reward-aversion states.
| Errataetall: |
CommentIn: Cell Res. 2022 Feb;32(2):115-116. - PMID 34949785 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Cell research - 32(2022), 2 vom: 30. Feb., Seite 139-156 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Zhiyuan [VerfasserIn] |
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| Links: |
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| Themen: |
Dopamine |
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| Anmerkungen: |
Date Completed 19.04.2022 Date Revised 11.02.2023 published: Print-Electronic CommentIn: Cell Res. 2022 Feb;32(2):115-116. - PMID 34949785 Citation Status MEDLINE |
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| doi: |
10.1038/s41422-021-00588-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333857801 |
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| 245 | 1 | 2 | |a A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state |
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| 500 | |a CommentIn: Cell Res. 2022 Feb;32(2):115-116. - PMID 34949785 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a Dopamine (DA) level in the nucleus accumbens (NAc) is critical for reward and aversion encoding. DA released from the ventral mesencephalon (VM) DAergic neurons increases the excitability of VM-projecting D1-dopamine receptor-expressing medium spiny neurons (D1-MSNs) in the NAc to enhance DA release and augment rewards. However, how such a DA positive feedback loop is regulated to maintain DA homeostasis and reward-aversion balance remains elusive. Here we report that the ventral pallidum (VP) projection of NAc D1-MSNs (D1NAc-VP) is inhibited by rewarding stimuli and activated by aversive stimuli. In contrast to the VM projection of D1-MSN (D1NAc-VM), activation of D1NAc-VP projection induces aversion, but not reward. D1NAc-VP MSNs are distinct from the D1NAc-VM MSNs, which exhibit conventional functions of D1-MSNs. Activation of D1NAc-VP projection stimulates VM GABAergic transmission, inhibits VM DAergic neurons, and reduces DA release into the NAc. Thus, D1NAc-VP and D1NAc-VM MSNs cooperatively control NAc dopamine balance and reward-aversion states | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Receptors, Dopamine D1 |2 NLM | |
| 650 | 7 | |a Dopamine |2 NLM | |
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| 700 | 1 | |a Lv, Yanbo |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xi |e verfasserin |4 aut | |
| 700 | 1 | |a Cui, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Yiming |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Deqin |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Chaonan |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Xiujuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Ruyi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jiayi |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Lan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xing |e verfasserin |4 aut | |
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