Real-world treatment of patients with palbociclib for HR+/HER2-advanced/metastatic breast cancer : the Europe IRIS study
Aim: To report the Europe Ibrance Real World Insights study findings. Methods: Physicians abstracted demographic/clinical characteristics, treatment and outcomes data for women with HR+/HER2- locally advanced breast cancer (ABC) or metastatic breast cancer (MBC) receiving palbociclib + aromatase inhibitor (AI) or palbociclib + fulvestrant. Kaplan-Meier analysis estimated progression-free rates (PFRs) and survival rates (SRs). Results: 238 physicians abstracted data for 1723 patients. For patients (>90%) initiating at 125 mg/day, dose was reduced in 18.9% of palbociclib + AI and 12.3% of palbociclib + fulvestrant patients. At 12 months, PFR for palbociclib + AI was 88.1%, and SR was 97.3%; PFR for palbociclib + fulvestrant was 79.8%, and SR was 97.5%. Conclusion: Low dose-reduction rates and favorable PFRs and SRs suggest that palbociclib + AI/fulvestrant is well tolerated and effective for HR+/HER2- ABC/MBC in real-world clinical practice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
|---|---|
| Enthalten in: |
Future oncology (London, England) - 18(2022), 3 vom: 17. Jan., Seite 349-362 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mycock, Katie [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.02.2022 Date Revised 28.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2217/fon-2021-0716 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333795113 |
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| 100 | 1 | |a Mycock, Katie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Real-world treatment of patients with palbociclib for HR+/HER2-advanced/metastatic breast cancer |b the Europe IRIS study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 28.02.2022 | ||
| 500 | |a Date Revised 28.02.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: To report the Europe Ibrance Real World Insights study findings. Methods: Physicians abstracted demographic/clinical characteristics, treatment and outcomes data for women with HR+/HER2- locally advanced breast cancer (ABC) or metastatic breast cancer (MBC) receiving palbociclib + aromatase inhibitor (AI) or palbociclib + fulvestrant. Kaplan-Meier analysis estimated progression-free rates (PFRs) and survival rates (SRs). Results: 238 physicians abstracted data for 1723 patients. For patients (>90%) initiating at 125 mg/day, dose was reduced in 18.9% of palbociclib + AI and 12.3% of palbociclib + fulvestrant patients. At 12 months, PFR for palbociclib + AI was 88.1%, and SR was 97.3%; PFR for palbociclib + fulvestrant was 79.8%, and SR was 97.5%. Conclusion: Low dose-reduction rates and favorable PFRs and SRs suggest that palbociclib + AI/fulvestrant is well tolerated and effective for HR+/HER2- ABC/MBC in real-world clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
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| 650 | 4 | |a medical chart review | |
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| 650 | 4 | |a palbociclib | |
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| 650 | 7 | |a Piperazines |2 NLM | |
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| 650 | 7 | |a Pyridines |2 NLM | |
| 650 | 7 | |a Receptors, Estrogen |2 NLM | |
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| 700 | 1 | |a Zhan, Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Hart, Kieran |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor-Stokes, Gavin |e verfasserin |4 aut | |
| 700 | 1 | |a Milligan, Gary |e verfasserin |4 aut | |
| 700 | 1 | |a Atkinson, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Mitra, Debanjali |e verfasserin |4 aut | |
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