Jellynolide A, pokepola esters, and sponalisolides from the aquaculture sponge Spongia officinalis L
Copyright © 2021. Published by Elsevier Ltd..
Jellynolide A, an unreported bicyclic diterpenoid with an unprecedented penta-substituted carbon skeleton which implied an irregular biogenic pathway, together with four pairs of rare phosphate triesters, (±)-pokepola ester B-E, one undescribed related racemic furanoterpenoid, (±)-sponalisolide C, one undescribed furanoterpenoid, (-)-sponalisolide D, and two known (±)-sponalisolide B and dendrolasin carboxylic acid were isolated from the aquaculture Spongia officinalis L. Their structures were elucidated by comprehensive spectroscopic analysis, quantum chemical calculation of NMR parameters, and electronic circular dichroism (ECD). The plausible biosynthetic pathway of jellynolide A was proposed. (±)-Pokepola ester C exhibited significant inhibition against Wnt, HIF1 signaling pathways. (+)-Pokepola ester B and (-)-pokepola ester D showed moderate cytotoxicity activities.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:194 |
|---|---|
| Enthalten in: |
Phytochemistry - 194(2022) vom: 01. Feb., Seite 113006 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jin, Tianyun [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
7440-44-0 |
|---|
| Anmerkungen: |
Date Completed 22.12.2021 Date Revised 22.12.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.phytochem.2021.113006 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM333748786 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM333748786 | ||
| 003 | DE-627 | ||
| 005 | 20231225222303.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.phytochem.2021.113006 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1112.xml |
| 035 | |a (DE-627)NLM333748786 | ||
| 035 | |a (NLM)34837765 | ||
| 035 | |a (PII)S0031-9422(21)00355-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Jin, Tianyun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Jellynolide A, pokepola esters, and sponalisolides from the aquaculture sponge Spongia officinalis L |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.12.2021 | ||
| 500 | |a Date Revised 22.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier Ltd. | ||
| 520 | |a Jellynolide A, an unreported bicyclic diterpenoid with an unprecedented penta-substituted carbon skeleton which implied an irregular biogenic pathway, together with four pairs of rare phosphate triesters, (±)-pokepola ester B-E, one undescribed related racemic furanoterpenoid, (±)-sponalisolide C, one undescribed furanoterpenoid, (-)-sponalisolide D, and two known (±)-sponalisolide B and dendrolasin carboxylic acid were isolated from the aquaculture Spongia officinalis L. Their structures were elucidated by comprehensive spectroscopic analysis, quantum chemical calculation of NMR parameters, and electronic circular dichroism (ECD). The plausible biosynthetic pathway of jellynolide A was proposed. (±)-Pokepola ester C exhibited significant inhibition against Wnt, HIF1 signaling pathways. (+)-Pokepola ester B and (-)-pokepola ester D showed moderate cytotoxicity activities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aquaculture sponge | |
| 650 | 4 | |a Biological activity | |
| 650 | 4 | |a Phosphate triester | |
| 650 | 4 | |a Spongia officinalis L. | |
| 650 | 4 | |a Spongidae | |
| 650 | 4 | |a Terpenoids | |
| 650 | 7 | |a Esters |2 NLM | |
| 650 | 7 | |a Carbon |2 NLM | |
| 650 | 7 | |a 7440-44-0 |2 NLM | |
| 700 | 1 | |a Li, Pinglin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Cili |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Xuli |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Xiaoli |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Fengqing |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Lianzhong |e verfasserin |4 aut | |
| 700 | 1 | |a Ou, Huilong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Guoqiang |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Phytochemistry |d 1986 |g 194(2022) vom: 01. Feb., Seite 113006 |w (DE-627)NLM013477943 |x 1873-3700 |7 nnns |
| 773 | 1 | 8 | |g volume:194 |g year:2022 |g day:01 |g month:02 |g pages:113006 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.phytochem.2021.113006 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 194 |j 2022 |b 01 |c 02 |h 113006 | ||