High Skin Sympathetic Nerve Activity in Patients with Recurrent Syncope
(1) Background: The autonomic imbalance plays a role in vasovagal syncope (VVS) diagnosed by head-up tilting test (HUT). neuECG is a new method of recording skin electrical signals to simultaneously analyze skin sympathetic nerve activity (SKNA) and electrocardiogram. We hypothesize that SKNA is higher in subjects with tilt-positive than tilt-negative and the SKNA surges before syncope. (2) Methods: We recorded neuECG in 41 subjects who received HUT (according to the "Italian protocol"), including rest, tilt-up, provocation and recovery phases. Data were analyzed to determine the average SKNA (aSKNA, μV) per digitized sample. Electrocardiogram was used to calculate standard deviation of normal-to-normal beat intervals (SDNN). The "SKNA-SDNN index" was calculated by rest aSKNA multiplied by the ratio of tilt-up to rest SDNN. (3) Results: 16 of 41 (39%) subjects developed syncope. The aSKNA at rest phase is significantly higher in the tilt-positive (1.21 ± 0.27 µV) than tilt-negative subjects (1.02 ± 0.29 µV) (p = 0.034). There are significant surges and withdraw of aSKNA 30 s before and after syncope (both p ≤ 0.006). SKNA-SDNN index is able to predict syncope (p < 0.001). (4) Conclusion: Higher SKNA at rest phase is associated with positive HUT. The SKNA-SDNN index is a novel marker to predict syncope during HUT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Journal of personalized medicine - 11(2021), 11 vom: 21. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huang, Tien-Chi [VerfasserIn] |
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| Links: |
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| Themen: |
Head-up tilting test |
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| Anmerkungen: |
Date Revised 30.11.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jpm11111053 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333715284 |
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| 520 | |a (1) Background: The autonomic imbalance plays a role in vasovagal syncope (VVS) diagnosed by head-up tilting test (HUT). neuECG is a new method of recording skin electrical signals to simultaneously analyze skin sympathetic nerve activity (SKNA) and electrocardiogram. We hypothesize that SKNA is higher in subjects with tilt-positive than tilt-negative and the SKNA surges before syncope. (2) Methods: We recorded neuECG in 41 subjects who received HUT (according to the "Italian protocol"), including rest, tilt-up, provocation and recovery phases. Data were analyzed to determine the average SKNA (aSKNA, μV) per digitized sample. Electrocardiogram was used to calculate standard deviation of normal-to-normal beat intervals (SDNN). The "SKNA-SDNN index" was calculated by rest aSKNA multiplied by the ratio of tilt-up to rest SDNN. (3) Results: 16 of 41 (39%) subjects developed syncope. The aSKNA at rest phase is significantly higher in the tilt-positive (1.21 ± 0.27 µV) than tilt-negative subjects (1.02 ± 0.29 µV) (p = 0.034). There are significant surges and withdraw of aSKNA 30 s before and after syncope (both p ≤ 0.006). SKNA-SDNN index is able to predict syncope (p < 0.001). (4) Conclusion: Higher SKNA at rest phase is associated with positive HUT. The SKNA-SDNN index is a novel marker to predict syncope during HUT | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a heart rate variability | |
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| 650 | 4 | |a vasovagal syncope | |
| 700 | 1 | |a Chi, Nai-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Chih-Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chang-Jen |e verfasserin |4 aut | |
| 700 | 1 | |a Jhuo, Shih-Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Tsung-Han |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yi-Hsueh |e verfasserin |4 aut | |
| 700 | 1 | |a Chou, Li-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Chien-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Liao, Wei-Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Kao, Pei-Heng |e verfasserin |4 aut | |
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