Synthesis and cytotoxicity evaluation of alpha beta unsaturated carboxylic acids of thiophene analogs by using polymer supported microwave-assisted method
α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive compounds whose speedy generation through novel synthetic techniques has become an enigma for the synthetic chemists. This research project demonstrates a novel method for the synthesis of these compounds using polymer-supported microwave-assisted methodology carried out through one-pot multicomponent reaction. Both soluble and insoluble polymers have been used and their results are comprehensively analyzed. Moreover, the compounds are characterized through spectral analysis like FTIR, GC-MASS, 1HNMR Spectroscopy. The cytotoxicity of synthesized compounds is evaluated through MTT assay using HEPG 2 cells.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Pakistan journal of pharmaceutical sciences - 34(2021), 4 vom: 16. Juli, Seite 1403-1407 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hassan, Jhanara [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 17.02.2022 Date Revised 17.02.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333366743 |
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| 245 | 1 | 0 | |a Synthesis and cytotoxicity evaluation of alpha beta unsaturated carboxylic acids of thiophene analogs by using polymer supported microwave-assisted method |
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| 500 | |a Date Revised 17.02.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a α- β unsaturated carboxylic acids containing a heterocyclic moiety is one of the most potent class of bioactive compounds whose speedy generation through novel synthetic techniques has become an enigma for the synthetic chemists. This research project demonstrates a novel method for the synthesis of these compounds using polymer-supported microwave-assisted methodology carried out through one-pot multicomponent reaction. Both soluble and insoluble polymers have been used and their results are comprehensively analyzed. Moreover, the compounds are characterized through spectral analysis like FTIR, GC-MASS, 1HNMR Spectroscopy. The cytotoxicity of synthesized compounds is evaluated through MTT assay using HEPG 2 cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Carboxylic Acids |2 NLM | |
| 650 | 7 | |a Cytotoxins |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Thiophenes |2 NLM | |
| 700 | 1 | |a Ehsan, Shahana |e verfasserin |4 aut | |
| 700 | 1 | |a Shahnaz, - |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Tahira Moen |e verfasserin |4 aut | |
| 700 | 1 | |a Saghir, Tahira |e verfasserin |4 aut | |
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