Prospective registry of adult patients receiving therapeutic plasma exchange with a presumptive diagnosis of thrombotic microangiopathy (TMA) : The Turkish hematology research and education group (ThREG)-TMA02 study
Copyright © 2021 Elsevier Ltd. All rights reserved..
Thrombotic microangiopathy(TMA) is a pathological diagnosis characterized by abnormalities of small vessels leading to microvascular thrombosis of arterioles and capillaries. The current prospective, non-interventional, multicenter (n:18) study aimed to define distribution of different TMA forms in adult Turkish patients who were referred for therapeutic plasma exchange (TPE) for a presumptive diagnosis of TMA. Patients with serum ADAMTS13 activity <5% were diagnosed as acquired thrombotic thrombocytopenic purpura (aTTP). Patients presenting with ADAMTS13 activity 6-10 % / normal renal function and patients with ADAMTS13 activity >10 %, normal renal function and no secondary TMA were treated as unclassified TMA. The study included a total of 97 patients (female: 60; male: 30) with a median age of 48 (18-74). Detailed evaluation at 1 month after hospital admission revealed aTTP, secondary TMA, infection/complement-associated hemolytic uremic syndrome and unclassified TMA in 32 (33 %), 33 (34 %), 26 (27 %) and 6 (6%) patients respectively. As subclassification of various TMAs will dictate specific therapy, proper diagnosis in a timely manner is of utmost clinical significance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2021 |
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| Enthalten in: |
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis - (2021) vom: 16. Nov., Seite 103312 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Akpınar, Seval [VerfasserIn] |
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| Links: |
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| Themen: |
Hematopoietic cell transplantation |
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| Anmerkungen: |
Date Revised 20.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.transci.2021.103312 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333366042 |
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| 520 | |a Thrombotic microangiopathy(TMA) is a pathological diagnosis characterized by abnormalities of small vessels leading to microvascular thrombosis of arterioles and capillaries. The current prospective, non-interventional, multicenter (n:18) study aimed to define distribution of different TMA forms in adult Turkish patients who were referred for therapeutic plasma exchange (TPE) for a presumptive diagnosis of TMA. Patients with serum ADAMTS13 activity <5% were diagnosed as acquired thrombotic thrombocytopenic purpura (aTTP). Patients presenting with ADAMTS13 activity 6-10 % / normal renal function and patients with ADAMTS13 activity >10 %, normal renal function and no secondary TMA were treated as unclassified TMA. The study included a total of 97 patients (female: 60; male: 30) with a median age of 48 (18-74). Detailed evaluation at 1 month after hospital admission revealed aTTP, secondary TMA, infection/complement-associated hemolytic uremic syndrome and unclassified TMA in 32 (33 %), 33 (34 %), 26 (27 %) and 6 (6%) patients respectively. As subclassification of various TMAs will dictate specific therapy, proper diagnosis in a timely manner is of utmost clinical significance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hematopoietic cell transplantation | |
| 650 | 4 | |a Hemolytic uremic syndrome | |
| 650 | 4 | |a Thrombotic microangiopathy | |
| 650 | 4 | |a Thrombotic thrombocytopenic purpura | |
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| 700 | 1 | |a Erkurt, Mehmet Ali |e verfasserin |4 aut | |
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| 700 | 1 | |a Yılmaz, Mehmet |e verfasserin |4 aut | |
| 700 | 1 | |a Karakus, Volkan |e verfasserin |4 aut | |
| 700 | 1 | |a Vural, Filiz |e verfasserin |4 aut | |
| 700 | 1 | |a Gediz, Fusun |e verfasserin |4 aut | |
| 700 | 1 | |a Aydogdu, Ismet |e verfasserin |4 aut | |
| 700 | 1 | |a Kaynar, Leylagul |e verfasserin |4 aut | |
| 700 | 1 | |a Korkmaz, Serdal |e verfasserin |4 aut | |
| 700 | 1 | |a Goker, Hakan |e verfasserin |4 aut | |
| 700 | 1 | |a Kelkitli, Engin |e verfasserin |4 aut | |
| 700 | 1 | |a Ayyıldız, Orhan |e verfasserin |4 aut | |
| 700 | 1 | |a Demirkan, Fatih |e verfasserin |4 aut | |
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