Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease
© 2021. The Author(s)..
BACKGROUND: Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease.
METHODS: An ongoing Dutch multicentre prospective cohort study enrols patients of ≥70 years with an eGFR < 20 mL/min/1.73m2 from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally.
RESULTS: The 82 included patients had a median age of 77.5 years (interquartile range 73.9-82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar.
CONCLUSIONS: Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important.
TRIAL REGISTRATION: The study is registered at the Netherlands Trial Register (NTR), trial number NL7104. Date of registration: 06-06-2018.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
BMC geriatrics - 21(2021), 1 vom: 19. Nov., Seite 650 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Voorend, C G N [VerfasserIn] |
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| Links: |
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| Themen: |
Aged |
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| Anmerkungen: |
Date Completed 24.11.2021 Date Revised 31.05.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12877-021-02593-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333361806 |
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| 245 | 1 | 0 | |a Impact of the COVID-19 pandemic on symptoms of anxiety and depression and health-related quality of life in older patients with chronic kidney disease |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 24.11.2021 | ||
| 500 | |a Date Revised 31.05.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a BACKGROUND: Older patients with advanced chronic kidney disease are at increased risk for a severe course of the coronavirus disease-2019 (COVID-19) and vulnerable to mental health problems. We aimed to investigate prevalence and associated patient (demographic and clinical) characteristics of mental wellbeing (health-related quality of life [HRQoL] and symptoms of depression and anxiety) before and during the COVID-19 pandemic in older patients with advanced chronic kidney disease | ||
| 520 | |a METHODS: An ongoing Dutch multicentre prospective cohort study enrols patients of ≥70 years with an eGFR < 20 mL/min/1.73m2 from October 2018 onward. With additional questionnaires during the pandemic (May-June 2020), disease-related concerns about COVID-19 and general anxiety symptoms were assessed cross-sectionally, and depressive symptoms, HRQoL, and emotional symptoms longitudinally | ||
| 520 | |a RESULTS: The 82 included patients had a median age of 77.5 years (interquartile range 73.9-82.1), 77% were male and none had tested positive for COVID-19. Cross-sectionally, 67% of the patients reported to be more anxious about COVID-19 because of their kidney disease, and 43% of the patients stated that their quality of life was reduced due to the COVID-19 pandemic. Compared to pre-COVID-19, the presence of depressive symptoms had increased (11 to 22%; p = .022) and physical HRQoL declined (M = 40.4, SD = 10.1 to M = 36.1, SD = 10.4; p < .001), particularly in males. Mental HRQoL (M = 50.3, SD = 9.6 to M = 50.4, SD = 9.9; p = .913) and emotional symptoms remained similar | ||
| 520 | |a CONCLUSIONS: Older patients with advanced chronic kidney disease suffered from disease-related anxiety about COVID-19, increased depressive symptoms and reduced physical HRQoL during the COVID-19 pandemic. The impact of the pandemic on this vulnerable patient group extends beyond increased mortality risk, and awareness of mental wellbeing is important | ||
| 520 | |a TRIAL REGISTRATION: The study is registered at the Netherlands Trial Register (NTR), trial number NL7104. Date of registration: 06-06-2018 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Chronic kidney diseases | |
| 650 | 4 | |a Coronavirus disease-2019 (COVID-19) pandemic | |
| 650 | 4 | |a Mental health | |
| 650 | 4 | |a Quality of life | |
| 700 | 1 | |a van Oevelen, M |e verfasserin |4 aut | |
| 700 | 1 | |a Nieberg, M |e verfasserin |4 aut | |
| 700 | 1 | |a Meuleman, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Franssen, C F M |e verfasserin |4 aut | |
| 700 | 1 | |a Joosten, H |e verfasserin |4 aut | |
| 700 | 1 | |a Berkhout-Byrne, N C |e verfasserin |4 aut | |
| 700 | 1 | |a Abrahams, A C |e verfasserin |4 aut | |
| 700 | 1 | |a Mooijaart, S P |e verfasserin |4 aut | |
| 700 | 1 | |a Bos, W J W |e verfasserin |4 aut | |
| 700 | 1 | |a van Buren, M |e verfasserin |4 aut | |
| 700 | 0 | |a POLDER investigators |e verfasserin |4 aut | |
| 700 | 1 | |a van Alphen, Arjan |e investigator |4 oth | |
| 700 | 1 | |a Berkhout-Byrne, Noeleen |e investigator |4 oth | |
| 700 | 1 | |a van Breda, G F |e investigator |4 oth | |
| 700 | 1 | |a van Buren, Marjolijn |e investigator |4 oth | |
| 700 | 1 | |a Boom, Henk |e investigator |4 oth | |
| 700 | 1 | |a Bos, Willem Jan |e investigator |4 oth | |
| 700 | 1 | |a Diepenbroek, Adry |e investigator |4 oth | |
| 700 | 1 | |a Emmelot-Vonk, Marielle |e investigator |4 oth | |
| 700 | 1 | |a Franssen, Casper |e investigator |4 oth | |
| 700 | 1 | |a Gaillard, Carlo A J M |e investigator |4 oth | |
| 700 | 1 | |a Groeneweg-Peeters, Nel |e investigator |4 oth | |
| 700 | 1 | |a Hoekstra, Bettie |e investigator |4 oth | |
| 700 | 1 | |a Hommes, Nienke |e investigator |4 oth | |
| 700 | 1 | |a Hoornaar, Francoise |e investigator |4 oth | |
| 700 | 1 | |a Joosten, Hanneke |e investigator |4 oth | |
| 700 | 1 | |a Lagro, Joep |e investigator |4 oth | |
| 700 | 1 | |a Litjens, Elisabeth |e investigator |4 oth | |
| 700 | 1 | |a Molenaar, Femke |e investigator |4 oth | |
| 700 | 1 | |a Mooijaart, Simon P |e investigator |4 oth | |
| 700 | 1 | |a Neradova, Aegida |e investigator |4 oth | |
| 700 | 1 | |a Peters, Mike |e investigator |4 oth | |
| 700 | 1 | |a Veldman, Wilma |e investigator |4 oth | |
| 700 | 1 | |a Voorend, Carlijn |e investigator |4 oth | |
| 700 | 1 | |a Westerbos, Lidwien |e investigator |4 oth | |
| 700 | 1 | |a Westerman-van der Wijden, Carlijne |e investigator |4 oth | |
| 700 | 1 | |a Wierdsma, Judith |e investigator |4 oth | |
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