The cumulative incidence of and risk factors for morphometric severe vertebral fractures in Japanese men and women : the ROAD study third and fourth surveys
© 2021. International Osteoporosis Foundation and National Osteoporosis Foundation..
This population-based cohort study with a 3-year follow-up revealed that the annual incidence rates of vertebral fracture (VF) and severe VF (sVF) were 5.9%/year and 1.7%/year, respectively. The presence of mild VF at the baseline was a significant risk factor for incident sVF in participants without prevalent sVF.
INTRODUCTION: This study aimed to estimate the incidence of morphometric vertebral fracture (VF) and severe VF (sVF) in men and women and clarify whether the presence of a mild VF (mVF) increases the risk of incident sVF.
METHODS: Data from the population-based cohort study, entitled the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study, were analyzed. In total, 1190 participants aged ≥ 40 years (mean age, 65.0 ± 11.2) years completed whole-spine lateral radiography both at the third (2012-2013, baseline) and fourth surveys performed 3 years later (2015-2016, follow-up). VF was defined using Genant's semi-quantitative (SQ) method: VF as SQ ≥ 1, mVF as SQ = 1, and sVF as SQ ≥ 2. Cumulative incidence of VF and sVF was estimated. Multivariate logistic regression analyses were performed to evaluate risk factors for incident sVF.
RESULTS: The baseline prevalence of mVF and sVF were 16.8% and 6.0%, respectively. The annual incidence rates of VF and sVF were 5.9%/year and 1.7%/year, respectively. The annual incidence rates of sVF in participants without prevalent VF, with prevalent mVF, and with prevalent sVF were 0.6%/year, 3.8%/year, and 11.7%/year (p < 0.001), respectively. Multivariate logistic regression analyses in participants without prevalent sVF showed that the adjusted odds ratios for incident sVF were 4.12 [95% confident interval 1.85-9.16] and 4.53 [1.49-13.77] if the number of prevalent mVF at the baseline was 1 and ≥ 2, respectively.
CONCLUSIONS: The annual incidence rates of VF and sVF were 5.9%/year and 1.7%/year, respectively. The presence of prevalent mVF was an independent risk factor for incident sVF.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA - 33(2022), 4 vom: 01. Apr., Seite 889-899 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Horii, C [VerfasserIn] |
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| Anmerkungen: |
Date Completed 21.03.2022 Date Revised 21.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00198-021-06143-7 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333347633 |
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| 100 | 1 | |a Horii, C |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The cumulative incidence of and risk factors for morphometric severe vertebral fractures in Japanese men and women |b the ROAD study third and fourth surveys |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 21.03.2022 | ||
| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. International Osteoporosis Foundation and National Osteoporosis Foundation. | ||
| 520 | |a This population-based cohort study with a 3-year follow-up revealed that the annual incidence rates of vertebral fracture (VF) and severe VF (sVF) were 5.9%/year and 1.7%/year, respectively. The presence of mild VF at the baseline was a significant risk factor for incident sVF in participants without prevalent sVF | ||
| 520 | |a INTRODUCTION: This study aimed to estimate the incidence of morphometric vertebral fracture (VF) and severe VF (sVF) in men and women and clarify whether the presence of a mild VF (mVF) increases the risk of incident sVF | ||
| 520 | |a METHODS: Data from the population-based cohort study, entitled the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study, were analyzed. In total, 1190 participants aged ≥ 40 years (mean age, 65.0 ± 11.2) years completed whole-spine lateral radiography both at the third (2012-2013, baseline) and fourth surveys performed 3 years later (2015-2016, follow-up). VF was defined using Genant's semi-quantitative (SQ) method: VF as SQ ≥ 1, mVF as SQ = 1, and sVF as SQ ≥ 2. Cumulative incidence of VF and sVF was estimated. Multivariate logistic regression analyses were performed to evaluate risk factors for incident sVF | ||
| 520 | |a RESULTS: The baseline prevalence of mVF and sVF were 16.8% and 6.0%, respectively. The annual incidence rates of VF and sVF were 5.9%/year and 1.7%/year, respectively. The annual incidence rates of sVF in participants without prevalent VF, with prevalent mVF, and with prevalent sVF were 0.6%/year, 3.8%/year, and 11.7%/year (p < 0.001), respectively. Multivariate logistic regression analyses in participants without prevalent sVF showed that the adjusted odds ratios for incident sVF were 4.12 [95% confident interval 1.85-9.16] and 4.53 [1.49-13.77] if the number of prevalent mVF at the baseline was 1 and ≥ 2, respectively | ||
| 520 | |a CONCLUSIONS: The annual incidence rates of VF and sVF were 5.9%/year and 1.7%/year, respectively. The presence of prevalent mVF was an independent risk factor for incident sVF | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Incidence | |
| 650 | 4 | |a Risk factor | |
| 650 | 4 | |a Vertebral fracture | |
| 700 | 1 | |a Iidaka, T |e verfasserin |4 aut | |
| 700 | 1 | |a Muraki, S |e verfasserin |4 aut | |
| 700 | 1 | |a Oka, H |e verfasserin |4 aut | |
| 700 | 1 | |a Asai, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Tsutsui, S |e verfasserin |4 aut | |
| 700 | 1 | |a Hashizume, H |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, H |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, M |e verfasserin |4 aut | |
| 700 | 1 | |a Kawaguchi, H |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, K |e verfasserin |4 aut | |
| 700 | 1 | |a Akune, T |e verfasserin |4 aut | |
| 700 | 1 | |a Oshima, Y |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, S |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshimura, Noriko |e verfasserin |4 aut | |
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