Conserved Antigenic Structure of Contemporary Wild Poliovirus Type 1 Strains Endemic in Pakistan
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: Elimination of poliovirus in Pakistan and Afghanistan is challenged by notions against the role of oral poliovirus vaccine (OPV) in eradicating contemporary wild poliovirus (WPV) strains.
METHODS: A total of 1055 WPV type 1 (WPV1) strains isolated between 2013 and 2018 were categorized into 68 antigenic groups and tested for neutralization by OPV-derived antibodies. Molecular docking was conducted to determine neutralization efficiency of antibodies against WPV. The clinical significance of WPV1 variants was assessed to ascertain their role in patient outcomes.
RESULTS: We found that 88% of WPV1 strains isolated from paralytic children belonged to a single antigenic lineage identical to the WPV1 strain detected in 1993. WPV1 antigenic variants were effectively neutralized by OPV-derived antibodies, with geometric mean titers comparable to the neutralization titers found for 3 strains in OPV (OPV1-3, 7.96-9.149 [95% confidence interval, 6.864-10.171]; WPV1 strains, 7.542-8.786 [6.493-9.869]). Docking examination underscored a strong antigen-antibody interaction despite variations within the viral protein 1 epitopes. There was no significant association (P = .78) with clinical prognosis among patients infected with antigenically diverse WPV1 strains and patient outcomes, including death.
CONCLUSIONS: Our findings substantiate the robustness of OPV for neutralizing the contemporary WPV1 strains endemic in Pakistan and Afghanistan. Vaccination coverage must be augmented to achieve early eradication.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:226 |
|---|---|
| Enthalten in: |
The Journal of infectious diseases - 226(2022), 5 vom: 13. Sept., Seite 843-851 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Alam, Muhammad Masroor [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Eradication |
|---|
| Anmerkungen: |
Date Completed 15.09.2022 Date Revised 25.09.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/infdis/jiab555 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM333289498 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM333289498 | ||
| 003 | DE-627 | ||
| 005 | 20231225221345.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/infdis/jiab555 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1110.xml |
| 035 | |a (DE-627)NLM333289498 | ||
| 035 | |a (NLM)34791319 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Alam, Muhammad Masroor |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Conserved Antigenic Structure of Contemporary Wild Poliovirus Type 1 Strains Endemic in Pakistan |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.09.2022 | ||
| 500 | |a Date Revised 25.09.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: Elimination of poliovirus in Pakistan and Afghanistan is challenged by notions against the role of oral poliovirus vaccine (OPV) in eradicating contemporary wild poliovirus (WPV) strains | ||
| 520 | |a METHODS: A total of 1055 WPV type 1 (WPV1) strains isolated between 2013 and 2018 were categorized into 68 antigenic groups and tested for neutralization by OPV-derived antibodies. Molecular docking was conducted to determine neutralization efficiency of antibodies against WPV. The clinical significance of WPV1 variants was assessed to ascertain their role in patient outcomes | ||
| 520 | |a RESULTS: We found that 88% of WPV1 strains isolated from paralytic children belonged to a single antigenic lineage identical to the WPV1 strain detected in 1993. WPV1 antigenic variants were effectively neutralized by OPV-derived antibodies, with geometric mean titers comparable to the neutralization titers found for 3 strains in OPV (OPV1-3, 7.96-9.149 [95% confidence interval, 6.864-10.171]; WPV1 strains, 7.542-8.786 [6.493-9.869]). Docking examination underscored a strong antigen-antibody interaction despite variations within the viral protein 1 epitopes. There was no significant association (P = .78) with clinical prognosis among patients infected with antigenically diverse WPV1 strains and patient outcomes, including death | ||
| 520 | |a CONCLUSIONS: Our findings substantiate the robustness of OPV for neutralizing the contemporary WPV1 strains endemic in Pakistan and Afghanistan. Vaccination coverage must be augmented to achieve early eradication | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Pakistan | |
| 650 | 4 | |a eradication | |
| 650 | 4 | |a oral poliovirus vaccine | |
| 650 | 4 | |a polio eradication initiative | |
| 650 | 4 | |a poliovirus | |
| 650 | 4 | |a vaccination | |
| 650 | 7 | |a Poliovirus Vaccine, Oral |2 NLM | |
| 700 | 1 | |a Ikram, Aamir |e verfasserin |4 aut | |
| 700 | 1 | |a Mahmood, Nayab |e verfasserin |4 aut | |
| 700 | 1 | |a Sharif, Salmaan |e verfasserin |4 aut | |
| 700 | 1 | |a Shaukat, Shahzad |e verfasserin |4 aut | |
| 700 | 1 | |a Fatmi, Muhammad Qaiser |e verfasserin |4 aut | |
| 700 | 1 | |a Angez, Mehar |e verfasserin |4 aut | |
| 700 | 1 | |a Khurshid, Adnan |e verfasserin |4 aut | |
| 700 | 1 | |a Rehman, Lubna |e verfasserin |4 aut | |
| 700 | 1 | |a Akhtar, Ribqa |e verfasserin |4 aut | |
| 700 | 1 | |a Mujtaba, Ghulam |e verfasserin |4 aut | |
| 700 | 1 | |a Arshad, Yasir |e verfasserin |4 aut | |
| 700 | 1 | |a Rana, Muhammad Suleman |e verfasserin |4 aut | |
| 700 | 1 | |a Yousaf, Aneela |e verfasserin |4 aut | |
| 700 | 1 | |a Zaidi, Syed Sohail Zahoor |e verfasserin |4 aut | |
| 700 | 1 | |a Salman, Muhammad |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The Journal of infectious diseases |d 1945 |g 226(2022), 5 vom: 13. Sept., Seite 843-851 |w (DE-627)NLM000005819 |x 1537-6613 |7 nnns |
| 773 | 1 | 8 | |g volume:226 |g year:2022 |g number:5 |g day:13 |g month:09 |g pages:843-851 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/infdis/jiab555 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 226 |j 2022 |e 5 |b 13 |c 09 |h 843-851 | ||