Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart
© 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies..
Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular matrix components and various other factors shaping the microenvironment of the heart. In silico analysis of intercellular communication based on single-cell RNA sequencing revealed that fibroblasts are the source of the majority of outgoing signals to other cell types. This observation suggests that fibroblasts play key roles in orchestrating cellular interactions that maintain organ homeostasis but that can also contribute to disease states. Here, we will review the current knowledge of fibroblast interactions in the healthy, diseased, and aging heart. We focus on the interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:596 |
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| Enthalten in: |
FEBS letters - 596(2022), 5 vom: 15. März, Seite 638-654 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nicin, Luka [VerfasserIn] |
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| Links: |
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| Themen: |
Aging |
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| Anmerkungen: |
Date Completed 03.05.2022 Date Revised 03.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/1873-3468.14234 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM333255720 |
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| 520 | |a © 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. | ||
| 520 | |a Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular matrix components and various other factors shaping the microenvironment of the heart. In silico analysis of intercellular communication based on single-cell RNA sequencing revealed that fibroblasts are the source of the majority of outgoing signals to other cell types. This observation suggests that fibroblasts play key roles in orchestrating cellular interactions that maintain organ homeostasis but that can also contribute to disease states. Here, we will review the current knowledge of fibroblast interactions in the healthy, diseased, and aging heart. We focus on the interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a cardiomyocytes | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a electrical coupling | |
| 650 | 4 | |a endothelial cells | |
| 650 | 4 | |a exosomes | |
| 650 | 4 | |a fibroblasts | |
| 650 | 4 | |a heart | |
| 650 | 4 | |a immune cells | |
| 650 | 4 | |a paracrine signaling | |
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| 700 | 1 | |a Luxán, Guillermo |e verfasserin |4 aut | |
| 700 | 1 | |a Dimmeler, Stefanie |e verfasserin |4 aut | |
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