Transient Global Amnesia (TGA) : Younger Age and Absence of Cerebral Microangiopathy Are Potentially Predisposing Factors for TGA Recurrence
Copyright © 2021 Rogalewski, Beyer, Friedrich, Plümer, Zuhorn, Klingebiel, Woermann, Bien, Greeve and Schäbitz..
Background: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of less than 24 h. TGA occurs as a single event in most cases. Prevalence rates of recurrent TGA vary widely from 5.4 to 27.1%. This retrospective study aimed to determine predictors for TGA recurrence. Methods: Cardiovascular risk profile and magnetic resonance imaging (MRI) of 340 hospitalized TGA patients between 2011 and 2020 were retrospectively analyzed. The median follow-up period amounted to 4.5 ± 2.7 years. Comparisons were made between TGA patients with and without subsequent recurrence. Results: TGA patients with subsequent recurrence were significantly younger (recurrent vs. single episode, 63.6 ± 8.6 years vs. 67.3 ± 10.5 years, p = 0.032) and showed a lower degree of cerebral microangiopathy compared to TGA patients without recurrence. The mean latency to recurrence was 3.0 years ± 2.1 years after the first episode. In a subgroup analysis, patients with at least five years of follow-up (N = 160, median follow-up period 7.0 ± 1.4 years) had a recurrence rate of 11.3%. A 24.5% risk of subsequent TGA recurrence in the following five years was determined for TGA patients up to 70 years of age without microangiopathic changes on MRI (Fazekas' score 0). Conclusion: Younger TGA patients without significant microangiopathy do have an increased recurrence risk. In turn, pre-existing cerebrovascular pathology, in the form of chronic hypertension and cerebral microangiopathy, seems to counteract TGA recurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in neurology - 12(2021) vom: 09., Seite 736563 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rogalewski, Andreas [VerfasserIn] |
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| Links: |
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| Themen: |
Cerebral microangiopathy |
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| Anmerkungen: |
Date Revised 17.11.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fneur.2021.736563 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333149599 |
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| 520 | |a Copyright © 2021 Rogalewski, Beyer, Friedrich, Plümer, Zuhorn, Klingebiel, Woermann, Bien, Greeve and Schäbitz. | ||
| 520 | |a Background: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of less than 24 h. TGA occurs as a single event in most cases. Prevalence rates of recurrent TGA vary widely from 5.4 to 27.1%. This retrospective study aimed to determine predictors for TGA recurrence. Methods: Cardiovascular risk profile and magnetic resonance imaging (MRI) of 340 hospitalized TGA patients between 2011 and 2020 were retrospectively analyzed. The median follow-up period amounted to 4.5 ± 2.7 years. Comparisons were made between TGA patients with and without subsequent recurrence. Results: TGA patients with subsequent recurrence were significantly younger (recurrent vs. single episode, 63.6 ± 8.6 years vs. 67.3 ± 10.5 years, p = 0.032) and showed a lower degree of cerebral microangiopathy compared to TGA patients without recurrence. The mean latency to recurrence was 3.0 years ± 2.1 years after the first episode. In a subgroup analysis, patients with at least five years of follow-up (N = 160, median follow-up period 7.0 ± 1.4 years) had a recurrence rate of 11.3%. A 24.5% risk of subsequent TGA recurrence in the following five years was determined for TGA patients up to 70 years of age without microangiopathic changes on MRI (Fazekas' score 0). Conclusion: Younger TGA patients without significant microangiopathy do have an increased recurrence risk. In turn, pre-existing cerebrovascular pathology, in the form of chronic hypertension and cerebral microangiopathy, seems to counteract TGA recurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cerebral microangiopathy | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a recurrence | |
| 650 | 4 | |a risk factor | |
| 650 | 4 | |a transient global amnesia | |
| 700 | 1 | |a Beyer, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Friedrich, Anja |e verfasserin |4 aut | |
| 700 | 1 | |a Plümer, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Zuhorn, Frédéric |e verfasserin |4 aut | |
| 700 | 1 | |a Klingebiel, Randolf |e verfasserin |4 aut | |
| 700 | 1 | |a Woermann, Friedrich G |e verfasserin |4 aut | |
| 700 | 1 | |a Bien, Christian G |e verfasserin |4 aut | |
| 700 | 1 | |a Greeve, Isabell |e verfasserin |4 aut | |
| 700 | 1 | |a Schäbitz, Wolf-Rüdiger |e verfasserin |4 aut | |
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