Safety and Efficacy of Kidney Transplants From Older Adult Living Donors : A Comparative Analysis of Donor and Recipient Outcomes
OBJECTIVES: We investigated the safety of donor nephrectomy from older adult donors (age ≥60 years), as well as long-term donor, recipient, and graft outcomes.
MATERIALS AND METHODS: We retrospectively analyzed data from 307 living donor kidney transplants from 1996 to 2016 and defined 2 cohorts based on donor age. Cohort A comprised donors aged 60 years and older, and cohort B comprised donors from 18 to 59 years old. We recorded donor and recipient perioperative complications, outcomes, and survival rates and used SPSS and MedCalc statistical software programs for data analyses.
RESULTS: The mean follow-up period for donor-recipient pairs in cohort A was 97 months (SD, 25.1 months) with median 108 months (IQR, 92-108 months) and in cohort B was 100.57 months (SD, 25.45 months) with median 120 months (IQR, 84-120 months). Mean donor age in cohort A was 64.13 years (SD, 3.78 years) with median 63 years (IQR, 61-66.5 years) and in cohort B was 41.08 years (SD, 9.15 years) with median 41 years (IQR, 34.5-48 years) (P < .001, cohort A vs B). Mean recipient age in cohort A was 47.65 years (SD, 14.26 years) with median 48.5 years (IQR, 35.5-61 years) and in cohort B was 43.55 years (SD, 13.15 years) with median 40.5 years (IQR, 33.5-54 years) (P < .001, cohort A vs B). Both cohorts showed no significant differences in perioperative donor and recipient complications. Renal function (measured as estimated glomerular filtration rate) in remaining native kidneys of cohort A showed no significant decline during median 8-year follow-up (P = .089 and P < .414, respectively). There were no significant differences in survival rates for donors, recipients, and grafts.
CONCLUSIONS: Living donor kidney transplant from older adult donors is safe and effective with good long-term patient and allograft survival.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation - 19(2021), 12 vom: 15. Dez., Seite 1257-1262 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ghazanfar, Abbas [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.04.2022 Date Revised 19.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.6002/ect.2021.0246 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Ghazanfar, Abbas |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Safety and Efficacy of Kidney Transplants From Older Adult Living Donors |b A Comparative Analysis of Donor and Recipient Outcomes |
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| 500 | |a Date Revised 19.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: We investigated the safety of donor nephrectomy from older adult donors (age ≥60 years), as well as long-term donor, recipient, and graft outcomes | ||
| 520 | |a MATERIALS AND METHODS: We retrospectively analyzed data from 307 living donor kidney transplants from 1996 to 2016 and defined 2 cohorts based on donor age. Cohort A comprised donors aged 60 years and older, and cohort B comprised donors from 18 to 59 years old. We recorded donor and recipient perioperative complications, outcomes, and survival rates and used SPSS and MedCalc statistical software programs for data analyses | ||
| 520 | |a RESULTS: The mean follow-up period for donor-recipient pairs in cohort A was 97 months (SD, 25.1 months) with median 108 months (IQR, 92-108 months) and in cohort B was 100.57 months (SD, 25.45 months) with median 120 months (IQR, 84-120 months). Mean donor age in cohort A was 64.13 years (SD, 3.78 years) with median 63 years (IQR, 61-66.5 years) and in cohort B was 41.08 years (SD, 9.15 years) with median 41 years (IQR, 34.5-48 years) (P < .001, cohort A vs B). Mean recipient age in cohort A was 47.65 years (SD, 14.26 years) with median 48.5 years (IQR, 35.5-61 years) and in cohort B was 43.55 years (SD, 13.15 years) with median 40.5 years (IQR, 33.5-54 years) (P < .001, cohort A vs B). Both cohorts showed no significant differences in perioperative donor and recipient complications. Renal function (measured as estimated glomerular filtration rate) in remaining native kidneys of cohort A showed no significant decline during median 8-year follow-up (P = .089 and P < .414, respectively). There were no significant differences in survival rates for donors, recipients, and grafts | ||
| 520 | |a CONCLUSIONS: Living donor kidney transplant from older adult donors is safe and effective with good long-term patient and allograft survival | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Abbas, Madiha |e verfasserin |4 aut | |
| 700 | 1 | |a Salih, Laylan |e verfasserin |4 aut | |
| 700 | 1 | |a Popoola, Joyce |e verfasserin |4 aut | |
| 700 | 1 | |a Wadoodi, Ashar |e verfasserin |4 aut | |
| 700 | 1 | |a Heap, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Phanish, Mysore |e verfasserin |4 aut | |
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