Whole adrenal extract for Addison's disease in the 1920s : Where is the cortisol?
Copyright © 2021 Elsevier Ltd. All rights reserved..
Prior to the development of synthetic corticosteroids, Addison's disease was treated with oral dessicated whole adrenal glands or crude extracts. These products could not have contained meaningful amounts of cortisol, yet some patients improved. There may be something in whole glands that can stimulate failing adrenals to make cortisol.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:158 |
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| Enthalten in: |
Medical hypotheses - 158(2021) vom: 09. Nov., Seite 110731 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Isaacs, Linda L [VerfasserIn] |
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Date Revised 20.02.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.mehy.2021.110731 |
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| 520 | |a Prior to the development of synthetic corticosteroids, Addison's disease was treated with oral dessicated whole adrenal glands or crude extracts. These products could not have contained meaningful amounts of cortisol, yet some patients improved. There may be something in whole glands that can stimulate failing adrenals to make cortisol | ||
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