The dual impact of Jordanian Ephedra alte for inhibiting pepsin and treating microbial infections
© 2021 The Authors..
Screening of phytochemical Ephedra alte crude extract by GC-MS and HPLC analysis indicated the presence of alkaloids, tannins, flavonoids, terpenoids, and phenolic acid in the extract. The total phenolic content of E. alte methanol extract was 39.43 mg of Gallic acid eq/g, crude E. alte with 56.74, and 2.42 µg Trolox equivalent antioxidant capacity (TEAC)/g of plant extract according to DPPH and FRAP assay, respectively. The antimicrobial activity of E. alte against Staphylococcus aureus, staphylococcus epidermidis, Escherichia coli, and Klebsiellaoxytoca demonstrated a mean zone diameter of inhibition ranging from 0 to 17 mm. The MIC of the extracts ranged from 0.5 to 1.0 mg/mL. E. alte extract inhibits pepsin enzyme activity with IC50 values of 213.67 µg/ml. This study revealed that E. alte extract has pepsin enzyme inhibitory, antibacterial, antioxidant activities. The current outcomes indicate that E. alte might be employed as a natural agent for managing GERD and infectious diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Saudi journal of biological sciences - 28(2021), 11 vom: 04. Nov., Seite 6245-6253 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Salman, Haya Ayyal [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-bacterial |
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| Anmerkungen: |
Date Revised 13.11.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.sjbs.2021.06.090 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM333026446 |
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| 100 | 1 | |a Salman, Haya Ayyal |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The dual impact of Jordanian Ephedra alte for inhibiting pepsin and treating microbial infections |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 13.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021 The Authors. | ||
| 520 | |a Screening of phytochemical Ephedra alte crude extract by GC-MS and HPLC analysis indicated the presence of alkaloids, tannins, flavonoids, terpenoids, and phenolic acid in the extract. The total phenolic content of E. alte methanol extract was 39.43 mg of Gallic acid eq/g, crude E. alte with 56.74, and 2.42 µg Trolox equivalent antioxidant capacity (TEAC)/g of plant extract according to DPPH and FRAP assay, respectively. The antimicrobial activity of E. alte against Staphylococcus aureus, staphylococcus epidermidis, Escherichia coli, and Klebsiellaoxytoca demonstrated a mean zone diameter of inhibition ranging from 0 to 17 mm. The MIC of the extracts ranged from 0.5 to 1.0 mg/mL. E. alte extract inhibits pepsin enzyme activity with IC50 values of 213.67 µg/ml. This study revealed that E. alte extract has pepsin enzyme inhibitory, antibacterial, antioxidant activities. The current outcomes indicate that E. alte might be employed as a natural agent for managing GERD and infectious diseases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anti-bacterial | |
| 650 | 4 | |a Anti-pepsin | |
| 650 | 4 | |a Antioxidants | |
| 650 | 4 | |a Ephedra alte | |
| 650 | 4 | |a GERD | |
| 650 | 4 | |a Natural agent | |
| 700 | 1 | |a Yaakop, Amira Suriaty |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Mustafa, Ahmed |e verfasserin |4 aut | |
| 700 | 1 | |a Tarawneh, Khaled |e verfasserin |4 aut | |
| 700 | 1 | |a Aladaileh, Saleem |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Rimawi, Fuad |e verfasserin |4 aut | |
| 700 | 1 | |a Alakhras, Fadi |e verfasserin |4 aut | |
| 700 | 1 | |a Abu-Lafi, Saleh |e verfasserin |4 aut | |
| 700 | 1 | |a Zarzour, Raghdaa Al |e verfasserin |4 aut | |
| 700 | 1 | |a Wahab, Habibah |e verfasserin |4 aut | |
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