Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose-streptozotocin induced diabetic rats
OBJECTIVE: This study investigated the antidiabetic effect of vanillin using in vitro, in silico, and in vivo experimental models.
METHODOLOGY: Type 2 diabetes (T2D) was induced in male Sprague-Dawley (SD) rats using fructose-streptozotocin (STZ), then orally administered low (150 mg/kg bodyweight) or high (300 mg/kg bodyweight) dose of vanillin for 5 weeks intervention period.
RESULTS: Vanillin suppressed the levels of blood glucose, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), aspartate transaminase (AST), creatinine, urea, uric acid, when elevated serum insulin, HDL-cholesterol, and concomitantly improved pancreatic β-cell function, glucose tolerance, and pancreatic morphology. It also elevated both serum and pancreatic tissue GSH level, SOD and catalase activities, and hepatic glycogen level, while depleting malondialdehyde level, α-amylase, lipase, acetylcholinesterase, ATPase, ENTPDase and 5'-nucleotidase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and glycogen phosphorylase activities.
CONCLUSIONS: The results indicate the potent antidiabetic effect of vanillin against T2D and its associated complications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:130 |
|---|---|
| Enthalten in: |
Archives of physiology and biochemistry - 130(2024), 2 vom: 01. März, Seite 169-182 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Salau, Veronica F [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 27.03.2024 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/13813455.2021.1988981 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM332901653 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM332901653 | ||
| 003 | DE-627 | ||
| 005 | 20240327235028.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/13813455.2021.1988981 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1350.xml |
| 035 | |a (DE-627)NLM332901653 | ||
| 035 | |a (NLM)34752171 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Salau, Veronica F |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose-streptozotocin induced diabetic rats |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.03.2024 | ||
| 500 | |a Date Revised 27.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: This study investigated the antidiabetic effect of vanillin using in vitro, in silico, and in vivo experimental models | ||
| 520 | |a METHODOLOGY: Type 2 diabetes (T2D) was induced in male Sprague-Dawley (SD) rats using fructose-streptozotocin (STZ), then orally administered low (150 mg/kg bodyweight) or high (300 mg/kg bodyweight) dose of vanillin for 5 weeks intervention period | ||
| 520 | |a RESULTS: Vanillin suppressed the levels of blood glucose, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), aspartate transaminase (AST), creatinine, urea, uric acid, when elevated serum insulin, HDL-cholesterol, and concomitantly improved pancreatic β-cell function, glucose tolerance, and pancreatic morphology. It also elevated both serum and pancreatic tissue GSH level, SOD and catalase activities, and hepatic glycogen level, while depleting malondialdehyde level, α-amylase, lipase, acetylcholinesterase, ATPase, ENTPDase and 5'-nucleotidase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and glycogen phosphorylase activities | ||
| 520 | |a CONCLUSIONS: The results indicate the potent antidiabetic effect of vanillin against T2D and its associated complications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antioxidative | |
| 650 | 4 | |a dyslipidaemia | |
| 650 | 4 | |a hyperglycaemia | |
| 650 | 4 | |a type 2 diabetes | |
| 650 | 4 | |a vanillin | |
| 650 | 7 | |a Streptozocin |2 NLM | |
| 650 | 7 | |a 5W494URQ81 |2 NLM | |
| 650 | 7 | |a vanillin |2 NLM | |
| 650 | 7 | |a CHI530446X |2 NLM | |
| 650 | 7 | |a Fructose |2 NLM | |
| 650 | 7 | |a 30237-26-4 |2 NLM | |
| 650 | 7 | |a Acetylcholinesterase |2 NLM | |
| 650 | 7 | |a EC 3.1.1.7 |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 650 | 7 | |a Hypoglycemic Agents |2 NLM | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 650 | 7 | |a Cholesterol |2 NLM | |
| 650 | 7 | |a 97C5T2UQ7J |2 NLM | |
| 650 | 7 | |a Benzaldehydes |2 NLM | |
| 700 | 1 | |a Erukainure, Ochuko L |e verfasserin |4 aut | |
| 700 | 1 | |a Olofinsan, Kolawole O |e verfasserin |4 aut | |
| 700 | 1 | |a Msomi, Nontokozo Z |e verfasserin |4 aut | |
| 700 | 1 | |a Ijomone, Omamuyovwi M |e verfasserin |4 aut | |
| 700 | 1 | |a Islam, Md Shahidul |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Archives of physiology and biochemistry |d 1997 |g 130(2024), 2 vom: 01. März, Seite 169-182 |w (DE-627)NLM075599813 |x 1744-4160 |7 nnns |
| 773 | 1 | 8 | |g volume:130 |g year:2024 |g number:2 |g day:01 |g month:03 |g pages:169-182 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/13813455.2021.1988981 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 130 |j 2024 |e 2 |b 01 |c 03 |h 169-182 | ||