HOPE in action : A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons..
Liver transplantation (LT) from donors-with-HIV to recipients-with-HIV (HIV D+/R+) is permitted under the HOPE Act. There are only three international single-case reports of HIV D+/R+ LT, each with limited follow-up. We performed a prospective multicenter pilot study comparing HIV D+/R+ to donors-without-HIV to recipients-with-HIV (HIV D-/R+) LT. We quantified patient survival, graft survival, rejection, serious adverse events (SAEs), human immunodeficiency virus (HIV) breakthrough, infections, and malignancies, using Cox and negative binomial regression with inverse probability of treatment weighting. Between March 2016-July 2019, there were 45 LTs (8 simultaneous liver-kidney) at 9 centers: 24 HIV D+/R+, 21 HIV D-/R+ (10 D- were false-positive). The median follow-up time was 23 months. Median recipient CD4 was 287 cells/µL with 100% on antiretroviral therapy; 56% were hepatitis C virus (HCV)-seropositive, 13% HCV-viremic. Weighted 1-year survival was 83.3% versus 100.0% in D+ versus D- groups (p = .04). There were no differences in one-year graft survival (96.0% vs. 100.0%), rejection (10.8% vs. 18.2%), HIV breakthrough (8% vs. 10%), or SAEs (all p > .05). HIV D+/R+ had more opportunistic infections, infectious hospitalizations, and cancer. In this multicenter pilot study of HIV D+/R+ LT, patient and graft survival were better than historical cohorts, however, a potential increase in infections and cancer merits further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 22(2022), 3 vom: 09. März, Seite 853-864 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Durand, Christine M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.04.2022 Date Revised 10.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/ajt.16886 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332798569 |
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| 100 | 1 | |a Durand, Christine M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a HOPE in action |b A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 19.04.2022 | ||
| 500 | |a Date Revised 10.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 The American Society of Transplantation and the American Society of Transplant Surgeons. | ||
| 520 | |a Liver transplantation (LT) from donors-with-HIV to recipients-with-HIV (HIV D+/R+) is permitted under the HOPE Act. There are only three international single-case reports of HIV D+/R+ LT, each with limited follow-up. We performed a prospective multicenter pilot study comparing HIV D+/R+ to donors-without-HIV to recipients-with-HIV (HIV D-/R+) LT. We quantified patient survival, graft survival, rejection, serious adverse events (SAEs), human immunodeficiency virus (HIV) breakthrough, infections, and malignancies, using Cox and negative binomial regression with inverse probability of treatment weighting. Between March 2016-July 2019, there were 45 LTs (8 simultaneous liver-kidney) at 9 centers: 24 HIV D+/R+, 21 HIV D-/R+ (10 D- were false-positive). The median follow-up time was 23 months. Median recipient CD4 was 287 cells/µL with 100% on antiretroviral therapy; 56% were hepatitis C virus (HCV)-seropositive, 13% HCV-viremic. Weighted 1-year survival was 83.3% versus 100.0% in D+ versus D- groups (p = .04). There were no differences in one-year graft survival (96.0% vs. 100.0%), rejection (10.8% vs. 18.2%), HIV breakthrough (8% vs. 10%), or SAEs (all p > .05). HIV D+/R+ had more opportunistic infections, infectious hospitalizations, and cancer. In this multicenter pilot study of HIV D+/R+ LT, patient and graft survival were better than historical cohorts, however, a potential increase in infections and cancer merits further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, N.I.H., Intramural | |
| 650 | 4 | |a clinical research/practice | |
| 650 | 4 | |a ethics and public policy | |
| 650 | 4 | |a infection and infectious agents - viral: hepatitis C | |
| 650 | 4 | |a infection and infectious agents - viral: human herpesvirus 8 (HHV-8) | |
| 650 | 4 | |a infection and infectious agents - viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) | |
| 650 | 4 | |a infectious disease | |
| 650 | 4 | |a liver disease | |
| 650 | 4 | |a liver disease: infectious | |
| 650 | 4 | |a liver transplantation/hepatology | |
| 700 | 1 | |a Florman, Sander |e verfasserin |4 aut | |
| 700 | 1 | |a Motter, Jennifer D |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Diane |e verfasserin |4 aut | |
| 700 | 1 | |a Ostrander, Darin |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Sile |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Tao |e verfasserin |4 aut | |
| 700 | 1 | |a Werbel, William A |e verfasserin |4 aut | |
| 700 | 1 | |a Cameron, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Ottmann, Shane |e verfasserin |4 aut | |
| 700 | 1 | |a Hamilton, James P |e verfasserin |4 aut | |
| 700 | 1 | |a Redd, Andrew D |e verfasserin |4 aut | |
| 700 | 1 | |a Bowring, Mary G |e verfasserin |4 aut | |
| 700 | 1 | |a Eby, Yolanda |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, Reinaldo E |e verfasserin |4 aut | |
| 700 | 1 | |a Doby, Brianna |e verfasserin |4 aut | |
| 700 | 1 | |a Labo, Nazzarena |e verfasserin |4 aut | |
| 700 | 1 | |a Whitby, Denise |e verfasserin |4 aut | |
| 700 | 1 | |a Miley, Wendell |e verfasserin |4 aut | |
| 700 | 1 | |a Friedman-Moraco, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Turgeon, Nicole |e verfasserin |4 aut | |
| 700 | 1 | |a Price, Jennifer C |e verfasserin |4 aut | |
| 700 | 1 | |a Chin-Hong, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Stock, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Stosor, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a Kirchner, Varvara A |e verfasserin |4 aut | |
| 700 | 1 | |a Pruett, Timothy |e verfasserin |4 aut | |
| 700 | 1 | |a Wojciechowski, David |e verfasserin |4 aut | |
| 700 | 1 | |a Elias, Nahel |e verfasserin |4 aut | |
| 700 | 1 | |a Wolfe, Cameron |e verfasserin |4 aut | |
| 700 | 1 | |a Quinn, Thomas C |e verfasserin |4 aut | |
| 700 | 1 | |a Odim, Jonah |e verfasserin |4 aut | |
| 700 | 1 | |a Morsheimer, Megan |e verfasserin |4 aut | |
| 700 | 1 | |a Mehta, Sapna A |e verfasserin |4 aut | |
| 700 | 1 | |a Rana, Meenakshi M |e verfasserin |4 aut | |
| 700 | 1 | |a Huprikar, Shirish |e verfasserin |4 aut | |
| 700 | 1 | |a Massie, Allan |e verfasserin |4 aut | |
| 700 | 1 | |a Tobian, Aaron A R |e verfasserin |4 aut | |
| 700 | 1 | |a Segev, Dorry L |e verfasserin |4 aut | |
| 700 | 0 | |a HOPE in Action Investigators |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Marcus |e investigator |4 oth | |
| 700 | 1 | |a Piquant, Dominique |e investigator |4 oth | |
| 700 | 1 | |a Edwards, Carolyn |e investigator |4 oth | |
| 700 | 1 | |a Ranganna, Karthik M |e investigator |4 oth | |
| 700 | 1 | |a Link, Katherine |e investigator |4 oth | |
| 700 | 1 | |a Pearson, Thomas |e investigator |4 oth | |
| 700 | 1 | |a Mehta, Aneesh K |e investigator |4 oth | |
| 700 | 1 | |a Lyon, G Marshall |e investigator |4 oth | |
| 700 | 1 | |a Kitchens, William |e investigator |4 oth | |
| 700 | 1 | |a Huckaby, Jeryl |e investigator |4 oth | |
| 700 | 1 | |a Elbein, Rivka |e investigator |4 oth | |
| 700 | 1 | |a Roberson, April |e investigator |4 oth | |
| 700 | 1 | |a Ferry, Elizabeth |e investigator |4 oth | |
| 700 | 1 | |a Adebiyi, Margaret |e investigator |4 oth | |
| 700 | 1 | |a Adebiyi, Oluwafisayo |e investigator |4 oth | |
| 700 | 1 | |a Kubal, Chandrahekhar |e investigator |4 oth | |
| 700 | 1 | |a Ambinder, Richard |e investigator |4 oth | |
| 700 | 1 | |a Barnaba, Brittany |e investigator |4 oth | |
| 700 | 1 | |a Bismut, Gilad |e investigator |4 oth | |
| 700 | 1 | |a Bollinger, Juli |e investigator |4 oth | |
| 700 | 1 | |a Boyarsky, Brian |e investigator |4 oth | |
| 700 | 1 | |a Charles, Curtisha |e investigator |4 oth | |
| 700 | 1 | |a Cochran, Willa V |e investigator |4 oth | |
| 700 | 1 | |a Desai, Niraj N |e investigator |4 oth | |
| 700 | 1 | |a Doby, Brianna |e investigator |4 oth | |
| 700 | 1 | |a Johnstone, Jaylyn |e investigator |4 oth | |
| 700 | 1 | |a Kirby, Charles |e investigator |4 oth | |
| 700 | 1 | |a Klock, Ethan |e investigator |4 oth | |
| 700 | 1 | |a Kusemiju, Oyinkansola |e investigator |4 oth | |
| 700 | 1 | |a Miller, Jernelle |e investigator |4 oth | |
| 700 | 1 | |a Morrison, Michelle |e investigator |4 oth | |
| 700 | 1 | |a Prizzi, Michelle |e investigator |4 oth | |
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| 700 | 1 | |a Sugarman, Jeremy |e investigator |4 oth | |
| 700 | 1 | |a Seaman, Shanti |e investigator |4 oth | |
| 700 | 1 | |a Thomas, Margret |e investigator |4 oth | |
| 700 | 1 | |a Akhran, Aleya |e investigator |4 oth | |
| 700 | 1 | |a Coakley, Margaret |e investigator |4 oth | |
| 700 | 1 | |a Cooper, Matthew |e investigator |4 oth | |
| 700 | 1 | |a Gilbert, Alexander |e investigator |4 oth | |
| 700 | 1 | |a Stucke, Alyssa |e investigator |4 oth | |
| 700 | 1 | |a Timpone, Joseph |e investigator |4 oth | |
| 700 | 1 | |a Castillo-Lugo, Jose A |e investigator |4 oth | |
| 700 | 1 | |a Townsend, Melba |e investigator |4 oth | |
| 700 | 1 | |a Haydel, Brandy M |e investigator |4 oth | |
| 700 | 1 | |a Goudy, Leah |e investigator |4 oth | |
| 700 | 1 | |a Gallon, Lorenzo |e investigator |4 oth | |
| 700 | 1 | |a Dieter, Rebecca |e investigator |4 oth | |
| 700 | 1 | |a Deterville, Cecilia |e investigator |4 oth | |
| 700 | 1 | |a Klein, Elizabeth |e investigator |4 oth | |
| 700 | 1 | |a Neumann, Henry |e investigator |4 oth | |
| 700 | 1 | |a Weldon, Elaina P |e investigator |4 oth | |
| 700 | 1 | |a Hand, Jonathan |e investigator |4 oth | |
| 700 | 1 | |a Smith, Angela R |e investigator |4 oth | |
| 700 | 1 | |a Blumberg, Emily A |e investigator |4 oth | |
| 700 | 1 | |a Donaghy, Eileen |e investigator |4 oth | |
| 700 | 1 | |a Dunn, Ty |e investigator |4 oth | |
| 700 | 1 | |a Sawinski, Deirdre |e investigator |4 oth | |
| 700 | 1 | |a Mall, Mark |e investigator |4 oth | |
| 700 | 1 | |a Santos, Carlos A Q |e investigator |4 oth | |
| 700 | 1 | |a Basinger, Katherine |e investigator |4 oth | |
| 700 | 1 | |a Locke, Jayme E |e investigator |4 oth | |
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| 700 | 1 | |a Spaggiari, Mario |e investigator |4 oth | |
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| 700 | 1 | |a Brogden, Gregory |e investigator |4 oth | |
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| 700 | 1 | |a Pakstis, Diana Lynn |e investigator |4 oth | |
| 700 | 1 | |a Silveira, Fernanda |e investigator |4 oth | |
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| 700 | 1 | |a Nagy, Jamie |e investigator |4 oth | |
| 700 | 1 | |a Baldecchi, Mary |e investigator |4 oth | |
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| 773 | 1 | 8 | |g volume:22 |g year:2022 |g number:3 |g day:09 |g month:03 |g pages:853-864 |
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