Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
© 2021. The Author(s)..
Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Cancer cell international - 21(2021), 1 vom: 04. Nov., Seite 595 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xuan, Xiuyun [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer progression |
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| Anmerkungen: |
Date Revised 09.11.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1186/s12935-021-02300-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332745570 |
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| 520 | |a © 2021. The Author(s). | ||
| 520 | |a Increasing evidence indicates that the tumor microenvironment appears to play an increasingly important role in cancer progression and therapeutic resistance. Several types of cells within the tumor stroma had distinct impacts on cancer progression, either promoting or inhibiting cancer cell growth. Mesenchymal stem cells (MSCs) are a distinct type of cells that is linked to tumor development. MSCs are recognized for homing to tumor locations and promoting or inhibiting cancer cell proliferation, angiogenesis and metastasis. Moreover, emerging studies suggests that MSCs are also involved in therapeutic resistance. In this review, we analyzed the existing researches and elaborate on the functions of MSCs in cancer progression and anticancer therapeutic resistance, demonstrating that MSCs may be a viable cancer therapeutic target | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Cancer progression | |
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| 650 | 4 | |a Mesenchymal stem cells | |
| 650 | 4 | |a Therapeutic resistance | |
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| 700 | 1 | |a Tian, Chunxia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Mengjie |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yanhong |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Changzheng |e verfasserin |4 aut | |
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