Acute Promyelocytic Leukemia with a BCR-ABL1 Rearrangement in a Minor Clone
© American Society for Clinical Pathology, 2021. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia characterized by predominating abnormal promyelocytes with a PML-RARA rearrangement or a variant thereof. BCR-ABL1 rearrangement is an oncogenic event that is usually associated with chronic myeloid leukemia but also occurs in both acute lymphoblastic and acute myeloid leukemias and in healthy individuals. However, APL with concurrent PML-RARA and BCR-ABL1 rearrangements has rarely been reported. Herein, we describe a patient with APL exhibiting a BCR-ABL1 rearrangement in a minor clone and discuss the importance of evaluating this genetic alteration in terms of pathogenesis and treatment.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
|---|---|
| Enthalten in: |
Laboratory medicine - 53(2022), 3 vom: 05. Mai, Seite 326-329 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cho, Yonggeun [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acute promyelocytic leukemia |
|---|
| Anmerkungen: |
Date Completed 09.05.2022 Date Revised 09.05.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/labmed/lmab097 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM332639258 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM332639258 | ||
| 003 | DE-627 | ||
| 005 | 20231225215959.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/labmed/lmab097 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1108.xml |
| 035 | |a (DE-627)NLM332639258 | ||
| 035 | |a (NLM)34725711 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cho, Yonggeun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute Promyelocytic Leukemia with a BCR-ABL1 Rearrangement in a Minor Clone |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.05.2022 | ||
| 500 | |a Date Revised 09.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © American Society for Clinical Pathology, 2021. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia characterized by predominating abnormal promyelocytes with a PML-RARA rearrangement or a variant thereof. BCR-ABL1 rearrangement is an oncogenic event that is usually associated with chronic myeloid leukemia but also occurs in both acute lymphoblastic and acute myeloid leukemias and in healthy individuals. However, APL with concurrent PML-RARA and BCR-ABL1 rearrangements has rarely been reported. Herein, we describe a patient with APL exhibiting a BCR-ABL1 rearrangement in a minor clone and discuss the importance of evaluating this genetic alteration in terms of pathogenesis and treatment | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a BCR-ABL1 | |
| 650 | 4 | |a PML-RARA | |
| 650 | 4 | |a acute promyelocytic leukemia | |
| 650 | 4 | |a concurrent | |
| 650 | 4 | |a minor clone | |
| 650 | 4 | |a treatment | |
| 700 | 1 | |a Hyun, Jungwon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Miyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Boram |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Young Kyung |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Laboratory medicine |d 1974 |g 53(2022), 3 vom: 05. Mai, Seite 326-329 |w (DE-627)NLM114369186 |x 1943-7730 |7 nnns |
| 773 | 1 | 8 | |g volume:53 |g year:2022 |g number:3 |g day:05 |g month:05 |g pages:326-329 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/labmed/lmab097 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 53 |j 2022 |e 3 |b 05 |c 05 |h 326-329 | ||