Chloroma of the Bladder : A Case Report of Leukemia Progression Presenting as Hematuria
Copyright © 2021 by S. Karger AG, Basel..
Myeloid sarcoma (MS) is a rare extramedullary manifestation of acute myelogenous leukemia (AML). The mass is composed of primitive myeloid cells that can occur in a variety of organs, most commonly the skin, lymph nodes, GI tract, bone, breast, and CNS. Involvement of the genitourinary tract is rare. Consensus on treatment of MS has not been established, but management typically involves systemic therapy, such as chemotherapy or allogeneic hematopoietic stem cell transplant as well as palliative local therapies such as radiation or surgery. Outcomes of MS using novel AML therapies, such as BCL-2 inhibitors or IDH inhibitors, remain undescribed. We describe a rare case of a 70-year-old man presenting with MS of the urinary bladder complicating known secondary AML (RUNX1 and IDH2 mutated). Prior to development of bladder MS, the patient had received decitabine, enasidenib, and venetoclax. Following diagnosis, he was treated with cytarabine and venetoclax. To our knowledge, this is the first case of bladder MS treated with a BCL-2 inhibitor.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Case reports in oncology - 14(2021), 3 vom: 26. Sept., Seite 1366-1372 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pearson, Laurie K [VerfasserIn] |
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| Links: |
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| Themen: |
Acute myelogenous leukemia |
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| Anmerkungen: |
Date Revised 02.11.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1159/000518529 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332591913 |
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| 100 | 1 | |a Pearson, Laurie K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chloroma of the Bladder |b A Case Report of Leukemia Progression Presenting as Hematuria |
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| 500 | |a Date Revised 02.11.2021 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2021 by S. Karger AG, Basel. | ||
| 520 | |a Myeloid sarcoma (MS) is a rare extramedullary manifestation of acute myelogenous leukemia (AML). The mass is composed of primitive myeloid cells that can occur in a variety of organs, most commonly the skin, lymph nodes, GI tract, bone, breast, and CNS. Involvement of the genitourinary tract is rare. Consensus on treatment of MS has not been established, but management typically involves systemic therapy, such as chemotherapy or allogeneic hematopoietic stem cell transplant as well as palliative local therapies such as radiation or surgery. Outcomes of MS using novel AML therapies, such as BCL-2 inhibitors or IDH inhibitors, remain undescribed. We describe a rare case of a 70-year-old man presenting with MS of the urinary bladder complicating known secondary AML (RUNX1 and IDH2 mutated). Prior to development of bladder MS, the patient had received decitabine, enasidenib, and venetoclax. Following diagnosis, he was treated with cytarabine and venetoclax. To our knowledge, this is the first case of bladder MS treated with a BCL-2 inhibitor | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Acute myelogenous leukemia | |
| 650 | 4 | |a Case report | |
| 650 | 4 | |a Extramedullary leukemia | |
| 650 | 4 | |a Myeloid sarcoma | |
| 650 | 4 | |a Rare bladder neoplasms | |
| 700 | 1 | |a Hamal, Ruchi |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Sanhong |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, Kenneth B |e verfasserin |4 aut | |
| 700 | 1 | |a Mensah, Felix |e verfasserin |4 aut | |
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