Effects of acute kidney injury on acute pancreatitis patients' survival rate in intensive care unit : A retrospective study
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved..
BACKGROUND: Acute kidney injury (AKI) is one of the most common acute pancreatitis (AP)-associated complications that has a significant effect on AP, but the factors affecting the AP patients' survival rate remains unclear.
AIM: To assess the influences of AKI on the survival rate in AP patients.
METHODS: A total of 139 AP patients were included in this retrospective study. Patients were divided into AKI group (n = 72) and non-AKI group (n = 67) according to the occurrence of AKI. Data were collected from medical records of hospitalized patients. Then, these data were compared between the two groups and further analysis was performed.
RESULTS: AKI is more likely to occur in male AP patients (P = 0.009). AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score, higher Sequential Organ Failure Assessment score, lower Glasgow Coma Scale score, and higher demand for mechanical ventilation, infusion of vasopressors, and renal replacement therapy than AP patients in non-AKI group (P < 0.01, P < 0.01, P = 0.01, P = 0.001, P < 0.01, P < 0.01, respectively). Significant differences were noted in dose of norepinephrine and adrenaline, duration of mechanical ventilation, maximum and mean values of intra-peritoneal pressure (IPP), maximum and mean values of procalcitonin, maximum and mean serum levels of creatinine, minimum platelet count, and length of hospitalization. Among AP patients with AKI, the survival rate of surgical intensive care unit and in-hospital were only 23% and 21% of the corresponding rates in AP patients without AKI, respectively. The factors that influenced the AP patients' survival rate included body mass index (BMI), mean values of IPP, minimum platelet count, and hospital day, of which mean values of IPP showed the greatest impact.
CONCLUSION: AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI, which necessitates further attention to AP patients with AKI in surgical intensive care unit.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
World journal of gastroenterology - 27(2021), 38 vom: 14. Okt., Seite 6453-6464 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shi, Ni [VerfasserIn] |
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| Links: |
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| Themen: |
Acute kidney injury |
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| Anmerkungen: |
Date Completed 02.11.2021 Date Revised 02.11.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.3748/wjg.v27.i38.6453 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332587827 |
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| 100 | 1 | |a Shi, Ni |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of acute kidney injury on acute pancreatitis patients' survival rate in intensive care unit |b A retrospective study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 02.11.2021 | ||
| 500 | |a Date Revised 02.11.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Acute kidney injury (AKI) is one of the most common acute pancreatitis (AP)-associated complications that has a significant effect on AP, but the factors affecting the AP patients' survival rate remains unclear | ||
| 520 | |a AIM: To assess the influences of AKI on the survival rate in AP patients | ||
| 520 | |a METHODS: A total of 139 AP patients were included in this retrospective study. Patients were divided into AKI group (n = 72) and non-AKI group (n = 67) according to the occurrence of AKI. Data were collected from medical records of hospitalized patients. Then, these data were compared between the two groups and further analysis was performed | ||
| 520 | |a RESULTS: AKI is more likely to occur in male AP patients (P = 0.009). AP patients in AKI group exhibited a significantly higher acute physiologic assessment and chronic health evaluation II score, higher Sequential Organ Failure Assessment score, lower Glasgow Coma Scale score, and higher demand for mechanical ventilation, infusion of vasopressors, and renal replacement therapy than AP patients in non-AKI group (P < 0.01, P < 0.01, P = 0.01, P = 0.001, P < 0.01, P < 0.01, respectively). Significant differences were noted in dose of norepinephrine and adrenaline, duration of mechanical ventilation, maximum and mean values of intra-peritoneal pressure (IPP), maximum and mean values of procalcitonin, maximum and mean serum levels of creatinine, minimum platelet count, and length of hospitalization. Among AP patients with AKI, the survival rate of surgical intensive care unit and in-hospital were only 23% and 21% of the corresponding rates in AP patients without AKI, respectively. The factors that influenced the AP patients' survival rate included body mass index (BMI), mean values of IPP, minimum platelet count, and hospital day, of which mean values of IPP showed the greatest impact | ||
| 520 | |a CONCLUSION: AP patients with AKI had a lower survival rate and worse relevant clinical outcomes than AP patients without AKI, which necessitates further attention to AP patients with AKI in surgical intensive care unit | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute kidney injury | |
| 650 | 4 | |a Acute pancreatitis | |
| 650 | 4 | |a Intra-peritoneal pressure | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Surgical intensive care unit | |
| 650 | 4 | |a Survival rate | |
| 700 | 1 | |a Sun, Guo-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Yuan-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Yu-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Wan-Qiu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Na-Na |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Qiu-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Zhi-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Zhen-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Jun-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Qing-Qing |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Gui-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yan-Song |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Hong-Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Yang |e verfasserin |4 aut | |
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