Utility of mouth rinses with povidone-iodine and hydrogen peroxide in patients with COVID-19
© 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved..
Introduction: Povidone-iodine and hydrogen peroxide could be effective in against SARS-CoV-2.
Methods: A "non-interventional trial" in 88 patients (43 ± 17 yrs, 55% men) with SARS-CoV-2 in nasopharyngeal swabs (RT-PCR). 31 received mouth rinses/gargling with povidone-iodine (every 8 h, two consecutive days), 17 with mouth rinses/gargling of hydrogen peroxide, and 40 controls. PCR were repeated at 3, 11 and 17 days.
Results: After intervention the viral load (Log 10 copies/ml) remained similar in povidone-iodine (4.3 ± 2.7 copies/ml), hydrogen peroxide (4.6 ± 2.9 copies/ml; p = 0.40) and controls (4.4 ± 3.0 copies/ml). The percentage of patients with a negative result in the second PCR was 27% in povidone-iodine group, 23% in hydrogen peroxide and 32% in controls; in the third PCR, 62%, 54% and 58% respectively; and in the fourth PCR, 81%, 75% and 81%.
Conclusion: Our results do not support the clinical usefulness of mouth rinses/gargling with povidone-iodine or hydrogen peroxide in patients with COVID-19.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
|---|---|
| Enthalten in: |
Enfermedades infecciosas y microbiologia clinica - 41(2023), 3 vom: 15. März, Seite 173-175 |
| Sprache: |
Spanisch |
|---|
| Weiterer Titel: |
Utilidad de los enjuagues con povidona yodada y peróxido de hidrógeno en pacientes con COVID-19 |
|---|
| Beteiligte Personen: |
Pablo-Marcos, Daniel [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Coronavirus |
|---|
| Anmerkungen: |
Date Revised 28.03.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1016/j.eimc.2021.10.005 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM332585565 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM332585565 | ||
| 003 | DE-627 | ||
| 005 | 20231225215855.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2023 xx |||||o 00| ||spa c | ||
| 024 | 7 | |a 10.1016/j.eimc.2021.10.005 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1108.xml |
| 035 | |a (DE-627)NLM332585565 | ||
| 035 | |a (NLM)34720312 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a spa | ||
| 100 | 1 | |a Pablo-Marcos, Daniel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Utility of mouth rinses with povidone-iodine and hydrogen peroxide in patients with COVID-19 |
| 246 | 3 | 3 | |a Utilidad de los enjuagues con povidona yodada y peróxido de hidrógeno en pacientes con COVID-19 |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 28.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a Introduction: Povidone-iodine and hydrogen peroxide could be effective in against SARS-CoV-2 | ||
| 520 | |a Methods: A "non-interventional trial" in 88 patients (43 ± 17 yrs, 55% men) with SARS-CoV-2 in nasopharyngeal swabs (RT-PCR). 31 received mouth rinses/gargling with povidone-iodine (every 8 h, two consecutive days), 17 with mouth rinses/gargling of hydrogen peroxide, and 40 controls. PCR were repeated at 3, 11 and 17 days | ||
| 520 | |a Results: After intervention the viral load (Log 10 copies/ml) remained similar in povidone-iodine (4.3 ± 2.7 copies/ml), hydrogen peroxide (4.6 ± 2.9 copies/ml; p = 0.40) and controls (4.4 ± 3.0 copies/ml). The percentage of patients with a negative result in the second PCR was 27% in povidone-iodine group, 23% in hydrogen peroxide and 32% in controls; in the third PCR, 62%, 54% and 58% respectively; and in the fourth PCR, 81%, 75% and 81% | ||
| 520 | |a Conclusion: Our results do not support the clinical usefulness of mouth rinses/gargling with povidone-iodine or hydrogen peroxide in patients with COVID-19 | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Hydrogen peroxide | |
| 650 | 4 | |a Load viral | |
| 650 | 4 | |a Mouth/rinses | |
| 650 | 4 | |a Povidone-iodine | |
| 700 | 1 | |a Abascal, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Lloret, Lara |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez Cuadra, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Velasco, Nieves |e verfasserin |4 aut | |
| 700 | 1 | |a Valero, Carmen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Enfermedades infecciosas y microbiologia clinica |d 1993 |g 41(2023), 3 vom: 15. März, Seite 173-175 |w (DE-627)NLM01273425X |x 1578-1852 |7 nnns |
| 773 | 1 | 8 | |g volume:41 |g year:2023 |g number:3 |g day:15 |g month:03 |g pages:173-175 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.eimc.2021.10.005 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 41 |j 2023 |e 3 |b 15 |c 03 |h 173-175 | ||