Association between PD-L1 inhibitor, tumor site and adverse events of potential immune etiology within the US FDA adverse event reporting system
Objective: To analyze tumor- and treatment-related factors that might impact the development of certain adverse events (AEs) of potential immune etiology among patients receiving PD-L1 inhibitors. Methods: The FDA Adverse Event Reporting System (FAERS) was accessed, and AE reports related to the use of PD-L1 inhibitors were reviewed. Associations between treatment, tumor type and occurrence of AEs of special interest were analyzed through multivariable logistic regression analysis. Results: A total of 80,304 AE reports were included in the current analysis. Diagnosis with lung cancer was associated with a higher probability of pneumonitis; diagnosis with melanoma was associated with a higher probability of hepatitis, hypophysitis/hypopituitarism and uveitis; and diagnosis with genitourinary cancers was associated with a higher probability of nephritis, adrenal insufficiency and myocarditis. Conclusion: Within this cohort limited to AEs reported to the FAERS, there is an association between different AEs of special interest, agent(s) used and tumor(s) treated.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
---|---|
Enthalten in: |
Immunotherapy - 13(2021), 17 vom: 01. Dez., Seite 1407-1417 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Abdel-Rahman, Omar [VerfasserIn] |
---|
Links: |
---|
Themen: |
Adverse events |
---|
Anmerkungen: |
Date Completed 21.03.2022 Date Revised 21.03.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.2217/imt-2021-0068 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM332474208 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM332474208 | ||
003 | DE-627 | ||
005 | 20231225215640.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.2217/imt-2021-0068 |2 doi | |
028 | 5 | 2 | |a pubmed24n1108.xml |
035 | |a (DE-627)NLM332474208 | ||
035 | |a (NLM)34709083 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Abdel-Rahman, Omar |e verfasserin |4 aut | |
245 | 1 | 0 | |a Association between PD-L1 inhibitor, tumor site and adverse events of potential immune etiology within the US FDA adverse event reporting system |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.03.2022 | ||
500 | |a Date Revised 21.03.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Objective: To analyze tumor- and treatment-related factors that might impact the development of certain adverse events (AEs) of potential immune etiology among patients receiving PD-L1 inhibitors. Methods: The FDA Adverse Event Reporting System (FAERS) was accessed, and AE reports related to the use of PD-L1 inhibitors were reviewed. Associations between treatment, tumor type and occurrence of AEs of special interest were analyzed through multivariable logistic regression analysis. Results: A total of 80,304 AE reports were included in the current analysis. Diagnosis with lung cancer was associated with a higher probability of pneumonitis; diagnosis with melanoma was associated with a higher probability of hepatitis, hypophysitis/hypopituitarism and uveitis; and diagnosis with genitourinary cancers was associated with a higher probability of nephritis, adrenal insufficiency and myocarditis. Conclusion: Within this cohort limited to AEs reported to the FAERS, there is an association between different AEs of special interest, agent(s) used and tumor(s) treated | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a FAERS | |
650 | 4 | |a PD-L1 inhibitors | |
650 | 4 | |a adverse events | |
650 | 4 | |a irAEs | |
650 | 4 | |a tumor sites | |
650 | 7 | |a Immune Checkpoint Inhibitors |2 NLM | |
650 | 7 | |a Neoplasm Proteins |2 NLM | |
650 | 7 | |a PDCD1 protein, human |2 NLM | |
650 | 7 | |a Programmed Cell Death 1 Receptor |2 NLM | |
773 | 0 | 8 | |i Enthalten in |t Immunotherapy |d 2009 |g 13(2021), 17 vom: 01. Dez., Seite 1407-1417 |w (DE-627)NLM19257163X |x 1750-7448 |7 nnns |
773 | 1 | 8 | |g volume:13 |g year:2021 |g number:17 |g day:01 |g month:12 |g pages:1407-1417 |
856 | 4 | 0 | |u http://dx.doi.org/10.2217/imt-2021-0068 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 13 |j 2021 |e 17 |b 01 |c 12 |h 1407-1417 |