Early microvascular changes in patients with prediabetes evaluated by optical coherence tomography angiography
© The Author(s), 2021..
BACKGROUND: Timely detection of early microvascular changes in patients with prediabetes could help reduce the likelihood of progression of diabetes-related retinal complications.
AIM: To determine early microvascular changes in patients with prediabetes using optical coherence tomography angiography (OCT-A).
METHODS: In this single-center retrospective case-control study, macular OCT-A images of superficial capillary plexus (SCP) and deep capillary plexus (DCP) were analyzed in non-diabetic controls, and prediabetic and diabetic subjects. A quantitative analysis was performed using ImageJ software of the foveal avascular zone (FAZ) area, acircularity index (AI), perfusion density (PD), and vascular length density (VLD).
RESULTS: A total of 94 eyes of 53 patients were included in this study. The global mean age was 57.7 years, 39.6% men and 60.4% women. In SCP, the mean PD was 0.283 ± 0.15, 0.186 ± 0.720, and 0.186 ± 0.07 in non-diabetic controls, and prediabetic and diabetic groups, respectively. The mean VLD was 8.728 ± 3.425 in non-diabetic controls, 6.147 ± 1.399 in prediabetic group, and 6.292 ± 1.997 in patients with diabetes. The comparison of prediabetic patients and controls shows statistical differences between PD and VLD in both plexus SCP (p = 0.002 and p = 0.001, respectively) and DCP (p = 0.005 and p = 0.002, respectively). The mean area of FAZ in patients with diabetes and normal individuals was 0.281 and 0.196 mm2, respectively (p < 0.001). AI was higher in the control group (0.87 ± 0.14) and prediabetic group (0.80 ± 0.17) compared to diabetic patients (0.64 ± 0.19). There were no differences in FAZ area and AI between prediabetic and non-diabetic controls.
CONCLUSION: PD and VLD demonstrated to be early microvascular changes in prediabetic patients evaluated by OCT-A. No alterations of FAZ were evidenced in this group.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Therapeutic advances in ophthalmology - 13(2021) vom: 01. Jan., Seite 25158414211047020 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Arias, Juan D [VerfasserIn] |
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| Links: |
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| Themen: |
Acircularity index |
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| Anmerkungen: |
Date Revised 27.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1177/25158414211047020 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332465330 |
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| 100 | 1 | |a Arias, Juan D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Early microvascular changes in patients with prediabetes evaluated by optical coherence tomography angiography |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 27.04.2022 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © The Author(s), 2021. | ||
| 520 | |a BACKGROUND: Timely detection of early microvascular changes in patients with prediabetes could help reduce the likelihood of progression of diabetes-related retinal complications | ||
| 520 | |a AIM: To determine early microvascular changes in patients with prediabetes using optical coherence tomography angiography (OCT-A) | ||
| 520 | |a METHODS: In this single-center retrospective case-control study, macular OCT-A images of superficial capillary plexus (SCP) and deep capillary plexus (DCP) were analyzed in non-diabetic controls, and prediabetic and diabetic subjects. A quantitative analysis was performed using ImageJ software of the foveal avascular zone (FAZ) area, acircularity index (AI), perfusion density (PD), and vascular length density (VLD) | ||
| 520 | |a RESULTS: A total of 94 eyes of 53 patients were included in this study. The global mean age was 57.7 years, 39.6% men and 60.4% women. In SCP, the mean PD was 0.283 ± 0.15, 0.186 ± 0.720, and 0.186 ± 0.07 in non-diabetic controls, and prediabetic and diabetic groups, respectively. The mean VLD was 8.728 ± 3.425 in non-diabetic controls, 6.147 ± 1.399 in prediabetic group, and 6.292 ± 1.997 in patients with diabetes. The comparison of prediabetic patients and controls shows statistical differences between PD and VLD in both plexus SCP (p = 0.002 and p = 0.001, respectively) and DCP (p = 0.005 and p = 0.002, respectively). The mean area of FAZ in patients with diabetes and normal individuals was 0.281 and 0.196 mm2, respectively (p < 0.001). AI was higher in the control group (0.87 ± 0.14) and prediabetic group (0.80 ± 0.17) compared to diabetic patients (0.64 ± 0.19). There were no differences in FAZ area and AI between prediabetic and non-diabetic controls | ||
| 520 | |a CONCLUSION: PD and VLD demonstrated to be early microvascular changes in prediabetic patients evaluated by OCT-A. No alterations of FAZ were evidenced in this group | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a acircularity index | |
| 650 | 4 | |a foveal avascular zone | |
| 650 | 4 | |a optical coherence tomography angiography | |
| 650 | 4 | |a perfusion density | |
| 650 | 4 | |a prediabetes | |
| 650 | 4 | |a vascular length density | |
| 700 | 1 | |a Arango, Francisco J |e verfasserin |4 aut | |
| 700 | 1 | |a Parra, Maria Margarita |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Ávila, Ronald M |e verfasserin |4 aut | |
| 700 | 1 | |a Parra-Serrano, Gustavo A |e verfasserin |4 aut | |
| 700 | 1 | |a Hoyos, Andrea T |e verfasserin |4 aut | |
| 700 | 1 | |a Granados, Silvia J |e verfasserin |4 aut | |
| 700 | 1 | |a Viteri, Eduardo J |e verfasserin |4 aut | |
| 700 | 1 | |a Gaibor-Santos, Ivetteh |e verfasserin |4 aut | |
| 700 | 1 | |a Perez, Yanny |e verfasserin |4 aut | |
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