Molecular Investigation of Human Cytomegalovirus and Epstein-Barr virus in Glioblastoma Brain Tumor : A Case-Control Study in Iran
Background: Glioblastoma multiforme is the most invasive and lethal form of brain cancer with unclear etiology. Our study aimed to investigate the molecular prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in patients with glioblastoma multiforme (GBM).
Methods: This case-control study was conducted on 42 FFPE brain tumor samples from GBM patients and 42 brain autopsies from subjects without neurological disorders. The presence of EBV and HCMV DNA was determined, using PCR and nested-PCR assays, respectively.
Results: HCMV DNA was detected in 3 out of 42 (7.1%) of GBM samples and was absent from the control group (p = 0.07). Importantly, EBV DNA was detected in 9 out of 42 (21.4%) brain tissue specimens of GBM subjects, but again in none of the control group (p = 0.001).
Conclusion: Our findings indicate that infection with EBV is associated with GBM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Iranian biomedical journal - 25(2021), 6 vom: 01. Nov., Seite 426-33 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ghaffari, Hadi [VerfasserIn] |
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| Links: |
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| Themen: |
Brain tumor |
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| Anmerkungen: |
Date Completed 04.02.2022 Date Revised 04.02.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.52547/ibj.25.6.426 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332366561 |
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| 100 | 1 | |a Ghaffari, Hadi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Molecular Investigation of Human Cytomegalovirus and Epstein-Barr virus in Glioblastoma Brain Tumor |b A Case-Control Study in Iran |
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| 500 | |a Date Completed 04.02.2022 | ||
| 500 | |a Date Revised 04.02.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Glioblastoma multiforme is the most invasive and lethal form of brain cancer with unclear etiology. Our study aimed to investigate the molecular prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in patients with glioblastoma multiforme (GBM) | ||
| 520 | |a Methods: This case-control study was conducted on 42 FFPE brain tumor samples from GBM patients and 42 brain autopsies from subjects without neurological disorders. The presence of EBV and HCMV DNA was determined, using PCR and nested-PCR assays, respectively | ||
| 520 | |a Results: HCMV DNA was detected in 3 out of 42 (7.1%) of GBM samples and was absent from the control group (p = 0.07). Importantly, EBV DNA was detected in 9 out of 42 (21.4%) brain tissue specimens of GBM subjects, but again in none of the control group (p = 0.001) | ||
| 520 | |a Conclusion: Our findings indicate that infection with EBV is associated with GBM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Brain tumor | |
| 650 | 4 | |a Epstein-Barr virus | |
| 650 | 4 | |a Glioblastoma | |
| 650 | 4 | |a Human cytomegalovirus | |
| 700 | 1 | |a Tavakoli, Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Faranoush, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Naderi, Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Kiani, Seyed Jalal |e verfasserin |4 aut | |
| 700 | 1 | |a Sadeghipour, Alireza |e verfasserin |4 aut | |
| 700 | 1 | |a Javanmard, Davod |e verfasserin |4 aut | |
| 700 | 1 | |a Farahmand, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Ghorbani, Saied |e verfasserin |4 aut | |
| 700 | 1 | |a Sedaghati, Farnoush |e verfasserin |4 aut | |
| 700 | 1 | |a Monavari, Seyed Hamidreza |e verfasserin |4 aut | |
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