Alcohol intake and stomach cancer risk in Japan : A pooled analysis of six cohort studies
© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association..
The association between alcohol intake and stomach cancer risk remains controversial. We undertook a pooled analysis of data from six large-scale Japanese cohort studies with 256 478 participants on this topic. Alcohol intake as ethanol was estimated using a validated questionnaire. The participants were followed for incidence of stomach cancer. We calculated study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for stomach cancer according to alcohol intake using a Cox regression model. Summary HRs were estimated by pooling the study-specific HRs using a random-effects model. During 4 265 551 person-years of follow-up, 8586 stomach cancer cases were identified. In men, the multivariate-adjusted HRs (95% CIs) of stomach cancer were 1.00 (0.87-1.15) for occasional drinkers, and 1.00 (0.91-1.11) for <23 g/d, 1.09 (1.01-1.18) for 23 to <46 g/d, 1.18 (1.09-1.29) for 46 to <69 g/d, 1.21 (1.05-1.39) for 69 to <92 g/d, and 1.29 (1.11-1.51) for ≥92 g/d ethanol in regular drinkers compared with nondrinkers. In women, the multivariate-adjusted HRs were 0.93 (0.80-1.08) for occasional drinkers, and 0.85 (0.74-0.99) for <23 g/d, and 1.22 (0.98-1.53) for ≥23 g/d in regular drinkers compared with nondrinkers. The HRs for proximal and distal cancer in drinkers vs nondrinkers were 1.69 (1.15-2.47) and 1.24 (0.99-1.55) for ≥92 g/d in men, and 1.60 (0.76-3.37) and 1.18 (0.88-1.57) for ≥23 g/d in women, respectively. Alcohol intake increased stomach cancer risk in men, and heavy drinkers showed a greater point estimate of risk for proximal cancer than for distal cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:113 |
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| Enthalten in: |
Cancer science - 113(2022), 1 vom: 15. Jan., Seite 261-276 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tamura, Takashi [VerfasserIn] |
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| Links: |
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| Themen: |
Alcohol intake |
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| Anmerkungen: |
Date Completed 12.01.2022 Date Revised 15.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/cas.15172 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM332294927 |
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| 100 | 1 | |a Tamura, Takashi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Alcohol intake and stomach cancer risk in Japan |b A pooled analysis of six cohort studies |
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| 500 | |a Date Revised 15.01.2022 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | ||
| 520 | |a The association between alcohol intake and stomach cancer risk remains controversial. We undertook a pooled analysis of data from six large-scale Japanese cohort studies with 256 478 participants on this topic. Alcohol intake as ethanol was estimated using a validated questionnaire. The participants were followed for incidence of stomach cancer. We calculated study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for stomach cancer according to alcohol intake using a Cox regression model. Summary HRs were estimated by pooling the study-specific HRs using a random-effects model. During 4 265 551 person-years of follow-up, 8586 stomach cancer cases were identified. In men, the multivariate-adjusted HRs (95% CIs) of stomach cancer were 1.00 (0.87-1.15) for occasional drinkers, and 1.00 (0.91-1.11) for <23 g/d, 1.09 (1.01-1.18) for 23 to <46 g/d, 1.18 (1.09-1.29) for 46 to <69 g/d, 1.21 (1.05-1.39) for 69 to <92 g/d, and 1.29 (1.11-1.51) for ≥92 g/d ethanol in regular drinkers compared with nondrinkers. In women, the multivariate-adjusted HRs were 0.93 (0.80-1.08) for occasional drinkers, and 0.85 (0.74-0.99) for <23 g/d, and 1.22 (0.98-1.53) for ≥23 g/d in regular drinkers compared with nondrinkers. The HRs for proximal and distal cancer in drinkers vs nondrinkers were 1.69 (1.15-2.47) and 1.24 (0.99-1.55) for ≥92 g/d in men, and 1.60 (0.76-3.37) and 1.18 (0.88-1.57) for ≥23 g/d in women, respectively. Alcohol intake increased stomach cancer risk in men, and heavy drinkers showed a greater point estimate of risk for proximal cancer than for distal cancer | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Japan | |
| 650 | 4 | |a alcohol intake | |
| 650 | 4 | |a cohort study | |
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| 700 | 1 | |a Wakai, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yingsong |e verfasserin |4 aut | |
| 700 | 1 | |a Tamakoshi, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Utada, Mai |e verfasserin |4 aut | |
| 700 | 1 | |a Ozasa, Kotaro |e verfasserin |4 aut | |
| 700 | 1 | |a Sugawara, Yumi |e verfasserin |4 aut | |
| 700 | 1 | |a Tsuji, Ichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Ayami |e verfasserin |4 aut | |
| 700 | 1 | |a Sawada, Norie |e verfasserin |4 aut | |
| 700 | 1 | |a Tsugane, Shoichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Hidemi |e verfasserin |4 aut | |
| 700 | 1 | |a Nagata, Chisato |e verfasserin |4 aut | |
| 700 | 1 | |a Kitamura, Tetsuhisa |e verfasserin |4 aut | |
| 700 | 1 | |a Naito, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Keitaro |e verfasserin |4 aut | |
| 700 | 1 | |a Shimazu, Taichi |e verfasserin |4 aut | |
| 700 | 1 | |a Mizoue, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuo, Keitaro |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Manami |e verfasserin |4 aut | |
| 700 | 0 | |a Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Sarah K |e investigator |4 oth | |
| 700 | 1 | |a Iwasaki, Motoki |e investigator |4 oth | |
| 700 | 1 | |a Muto, Michihiro |e investigator |4 oth | |
| 700 | 1 | |a Saito, Eiko |e investigator |4 oth | |
| 700 | 1 | |a Tanaka, Shiori |e investigator |4 oth | |
| 700 | 1 | |a Yamaji, Taiki |e investigator |4 oth | |
| 700 | 1 | |a Charvat, Hadrien |e investigator |4 oth | |
| 700 | 1 | |a Otani, Tetsuya |e investigator |4 oth | |
| 700 | 1 | |a Sasazuki, Shizuka |e investigator |4 oth | |
| 700 | 1 | |a Nishino, Yoshikazu |e investigator |4 oth | |
| 700 | 1 | |a Tsubono, Yoshitaka |e investigator |4 oth | |
| 700 | 1 | |a Nomura, Shuhei |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, Hidekazu |e investigator |4 oth | |
| 700 | 1 | |a Oze, Isao |e investigator |4 oth | |
| 700 | 1 | |a Wada, Keiko |e investigator |4 oth | |
| 700 | 1 | |a Kitamura, Yuri |e investigator |4 oth | |
| 700 | 1 | |a Nakayama, Tomio |e investigator |4 oth | |
| 700 | 1 | |a Sadakane, Atsuko |e investigator |4 oth | |
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