Multi-Omics Analysis to Generate Hypotheses for Mild Health Problems in Monkeys
Certain symptoms associated with mild sickness and lethargy have not been categorized as definitive diseases. Confirming such symptoms in captive monkeys (Macaca fascicularis, known as cynomolgus monkeys) can be difficult; however, it is possible to observe and analyze their feces. In this study, we investigated the relationship between stool state and various omics data by considering objective and quantitative values of stool water content as a phenotype for analysis. By examining the food intake of the monkeys and assessing their stool, urine, and plasma, we attempted to obtain a comprehensive understanding of the health status of individual monkeys and correlate it with the stool condition. Our metabolomics data strongly suggested that many lipid-related metabolites were correlated with the stool water content. The lipidomic analysis revealed the involvement of saturated and oxidized fatty acids, metallomics revealed the contribution of selenium (a bio-essential trace element), and intestinal microbiota analysis revealed the association of several bacterial species with the stool water content. Based on our results, we hypothesize that the redox imbalance causes minor health problems. However, it is not possible to make a definite conclusion using multi-omics alone, and other hypotheses could be proposed.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Metabolites - 11(2021), 10 vom: 13. Okt. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hamano, Fumie [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Revised 26.10.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/metabo11100701 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM332175715 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM332175715 | ||
| 003 | DE-627 | ||
| 005 | 20231225215044.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/metabo11100701 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1107.xml |
| 035 | |a (DE-627)NLM332175715 | ||
| 035 | |a (NLM)34677416 | ||
| 035 | |a (PII)701 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hamano, Fumie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multi-Omics Analysis to Generate Hypotheses for Mild Health Problems in Monkeys |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 26.10.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Certain symptoms associated with mild sickness and lethargy have not been categorized as definitive diseases. Confirming such symptoms in captive monkeys (Macaca fascicularis, known as cynomolgus monkeys) can be difficult; however, it is possible to observe and analyze their feces. In this study, we investigated the relationship between stool state and various omics data by considering objective and quantitative values of stool water content as a phenotype for analysis. By examining the food intake of the monkeys and assessing their stool, urine, and plasma, we attempted to obtain a comprehensive understanding of the health status of individual monkeys and correlate it with the stool condition. Our metabolomics data strongly suggested that many lipid-related metabolites were correlated with the stool water content. The lipidomic analysis revealed the involvement of saturated and oxidized fatty acids, metallomics revealed the contribution of selenium (a bio-essential trace element), and intestinal microbiota analysis revealed the association of several bacterial species with the stool water content. Based on our results, we hypothesize that the redox imbalance causes minor health problems. However, it is not possible to make a definite conclusion using multi-omics alone, and other hypotheses could be proposed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a lipid mediators | |
| 650 | 4 | |a lipidomics | |
| 650 | 4 | |a metabolomics | |
| 650 | 4 | |a metallomics | |
| 650 | 4 | |a microbiota | |
| 650 | 4 | |a multi-omics | |
| 650 | 4 | |a multiple sample sources | |
| 650 | 4 | |a redox | |
| 650 | 4 | |a saturated fatty acids | |
| 650 | 4 | |a selenium | |
| 700 | 1 | |a Tokuoka, Suzumi M |e verfasserin |4 aut | |
| 700 | 1 | |a Ishibashi, Megumi |e verfasserin |4 aut | |
| 700 | 1 | |a Yokoi, Yasuto |e verfasserin |4 aut | |
| 700 | 1 | |a Tourlousse, Dieter M |e verfasserin |4 aut | |
| 700 | 1 | |a Kita, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Sekiguchi, Yuji |e verfasserin |4 aut | |
| 700 | 1 | |a Yasui, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Shimizu, Takao |e verfasserin |4 aut | |
| 700 | 1 | |a Oda, Yoshiya |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Metabolites |d 2011 |g 11(2021), 10 vom: 13. Okt. |w (DE-627)NLM220344280 |x 2218-1989 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2021 |g number:10 |g day:13 |g month:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/metabo11100701 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2021 |e 10 |b 13 |c 10 | ||