Treatment with low-dose isotretinoin is effective for patients with moderate inflammatory acne
The recommended isotretinon dose for severe (nodulocystic) acne has for almost 40 years been 0,5-1,0 mg/kg/day reaching a cumulative dose of 120-150 mg/kg. Moderately severe acne has been treated with long-term systemic antibiotics, which carries a risk for microbial resistance in skin och intestinal flora. The Swedish Medical Products Agency approved in 2014 that patients with acne recurring after oral antibiotics given for at most two 3-month periods can be considered for isotretinoin treatment, but the dose regimen was not changed. These patients have moderate inflammatory acne (papulopustular) and studies over the recent years have shown that treatment with low-dose isotretinoin, 0,2-0,4 mg/kg/day, until acne recovery and independent of cumulative dose is effective. There are less frequent and less severe mucocutaneous side-effects, reduced risk of acne flares and it is considerably less expensive than traditional dosing. The duration of treatment is however prolonged, and the pregnancy prevention program must be followed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:118 |
|---|---|
| Enthalten in: |
Lakartidningen - 118(2021) vom: 21. Okt. |
| Sprache: |
Schwedisch |
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| Weiterer Titel: |
Isotretinoin i lågdos effektivt vid akne efter antibiotikakurer |
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| Beteiligte Personen: |
Mobacken, Håkan [VerfasserIn] |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 25.10.2021 Date Revised 31.05.2022 published: Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The recommended isotretinon dose for severe (nodulocystic) acne has for almost 40 years been 0,5-1,0 mg/kg/day reaching a cumulative dose of 120-150 mg/kg. Moderately severe acne has been treated with long-term systemic antibiotics, which carries a risk for microbial resistance in skin och intestinal flora. The Swedish Medical Products Agency approved in 2014 that patients with acne recurring after oral antibiotics given for at most two 3-month periods can be considered for isotretinoin treatment, but the dose regimen was not changed. These patients have moderate inflammatory acne (papulopustular) and studies over the recent years have shown that treatment with low-dose isotretinoin, 0,2-0,4 mg/kg/day, until acne recovery and independent of cumulative dose is effective. There are less frequent and less severe mucocutaneous side-effects, reduced risk of acne flares and it is considerably less expensive than traditional dosing. The duration of treatment is however prolonged, and the pregnancy prevention program must be followed | ||
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