Advanced interatrial block predicts recurrence of embolic stroke of undetermined source
Copyright © 2019 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved..
BACKGROUND: Advanced interatrial block (IAB) is an independent risk factor for ischaemic stroke. This study aimed to analyse whether advanced IAB predicts recurrence of embolic stroke of undetermined source (ESUS).
METHODS: 104 patients with a confirmed diagnosis of ESUS were followed up for a median period of 15 months (interquartile range, 10-48). We recorded data on clinical variables, P-wave characteristics, and presence of IAB on the electrocardiogram (ECG). ECG findings were interpreted by a blinded, centralised rater at (XXXX2). ESUS recurrence was the primary outcome variable.
RESULTS: Median age was 47 years (range, 19-85); 50% of patients were women. IAB was detected in 36 patients (34.6%); IAB was partial in 29 cases (27.9%) and advanced in 7 (6.7%). Sixteen patients (15.4%) presented stroke recurrence; of these, 5 had partial and 4 had advanced IAB (P = .01; odds ratio [OR] = 9.44; 95% confidence interval [CI], 1.88-47.46; relative risk [RR] = 4.62; 95% CI, 2.01-10.61). Median P-wave duration was longer in patients with stroke recurrence (P = .009). The multivariate logistic regression analysis identified the following independent risk factors for stroke recurrence: advanced IAB (P < .001; OR = 10.86; 95% CI, 3.07-38.46), male sex (P = .028; OR = 4.6; 95% CI, 1.18-17.96), and age older than 50 years (P = .039; OR = 3.84; 95% CI, 1.06-13.88). In the Cox proportional hazards model, the risk variables identified were age older than 50 years (P = .002; hazard ratio, 7.04; 95% CI, 2.06-23.8) and P-wave duration (per ms) (P = .007; hazard ratio, 1.02; 95% CI, 1.01-1.04).
CONCLUSIONS: Advanced IAB and age older than 50 years predict ESUS recurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Neurologia - 37(2022), 8 vom: 08. Okt., Seite 647-652 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Carrillo-Loza, K [VerfasserIn] |
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| Links: |
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| Themen: |
Bayés syndrome |
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| Anmerkungen: |
Date Completed 06.10.2022 Date Revised 06.10.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.nrleng.2019.10.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM331969483 |
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| 245 | 1 | 0 | |a Advanced interatrial block predicts recurrence of embolic stroke of undetermined source |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 06.10.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Sociedad Española de Neurología. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a BACKGROUND: Advanced interatrial block (IAB) is an independent risk factor for ischaemic stroke. This study aimed to analyse whether advanced IAB predicts recurrence of embolic stroke of undetermined source (ESUS) | ||
| 520 | |a METHODS: 104 patients with a confirmed diagnosis of ESUS were followed up for a median period of 15 months (interquartile range, 10-48). We recorded data on clinical variables, P-wave characteristics, and presence of IAB on the electrocardiogram (ECG). ECG findings were interpreted by a blinded, centralised rater at (XXXX2). ESUS recurrence was the primary outcome variable | ||
| 520 | |a RESULTS: Median age was 47 years (range, 19-85); 50% of patients were women. IAB was detected in 36 patients (34.6%); IAB was partial in 29 cases (27.9%) and advanced in 7 (6.7%). Sixteen patients (15.4%) presented stroke recurrence; of these, 5 had partial and 4 had advanced IAB (P = .01; odds ratio [OR] = 9.44; 95% confidence interval [CI], 1.88-47.46; relative risk [RR] = 4.62; 95% CI, 2.01-10.61). Median P-wave duration was longer in patients with stroke recurrence (P = .009). The multivariate logistic regression analysis identified the following independent risk factors for stroke recurrence: advanced IAB (P < .001; OR = 10.86; 95% CI, 3.07-38.46), male sex (P = .028; OR = 4.6; 95% CI, 1.18-17.96), and age older than 50 years (P = .039; OR = 3.84; 95% CI, 1.06-13.88). In the Cox proportional hazards model, the risk variables identified were age older than 50 years (P = .002; hazard ratio, 7.04; 95% CI, 2.06-23.8) and P-wave duration (per ms) (P = .007; hazard ratio, 1.02; 95% CI, 1.01-1.04) | ||
| 520 | |a CONCLUSIONS: Advanced IAB and age older than 50 years predict ESUS recurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bayés syndrome | |
| 650 | 4 | |a Bloqueo interatrial | |
| 650 | 4 | |a ESUS | |
| 650 | 4 | |a Ictus | |
| 650 | 4 | |a Infarto cerebral embolico de origen no determinado | |
| 650 | 4 | |a Interatrial block | |
| 650 | 4 | |a Recurrence | |
| 650 | 4 | |a Recurrencia | |
| 650 | 4 | |a Stroke | |
| 650 | 4 | |a Síndrome de Bayés | |
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| 700 | 1 | |a Serrano, F |e verfasserin |4 aut | |
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| 700 | 1 | |a Espinosa Lira, F |e verfasserin |4 aut | |
| 700 | 1 | |a Soriano, E |e verfasserin |4 aut | |
| 700 | 1 | |a Arauz, A |e verfasserin |4 aut | |
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