A Case Report of Serological Rapid Diagnostic Test-Negative Plasmodium malariae Malaria Imported from West Africa
BACKGROUND: The imported cases of Plasmodium malariae (P. malariae) and Plasmodium ovale (P. ovale) malaria are increasing annually, especially in central China. Here, we report a case of serological rapid diagnostic test (RDT)-negative P. malariae malaria imported from West Africa.
METHODS: The case patient was exclusively diagnosed with P. malariae through microscopy, Plasmodium genus-specific nested polymerase chain reaction (PCR), and sequencing of targeted P. malariae circumsporozoite (pmcsp) gene, except for serological RDT.
RESULTS: The patient was discharged in stable condition after 5 days of hospitalization, with no overt malaria parasites or associated symptoms.
CONCLUSIONS: This case reveals that asymptomatic P. malariae infections can occur among exported laborers back from malaria-endemic areas, some of whom may escape serological screening test or RDT, posing a continuing potential threat to malaria control. Therefore, PCR-based molecular techniques are more effective and necessary than serological RDT for malaria surveillance nationwide.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Clinical laboratory - 67(2021), 10 vom: 01. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xia, Jinxing [VerfasserIn] |
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| Anmerkungen: |
Date Completed 19.10.2021 Date Revised 19.10.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.7754/Clin.Lab.2021.210208 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 2 | |a A Case Report of Serological Rapid Diagnostic Test-Negative Plasmodium malariae Malaria Imported from West Africa |
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| 500 | |a Date Revised 19.10.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The imported cases of Plasmodium malariae (P. malariae) and Plasmodium ovale (P. ovale) malaria are increasing annually, especially in central China. Here, we report a case of serological rapid diagnostic test (RDT)-negative P. malariae malaria imported from West Africa | ||
| 520 | |a METHODS: The case patient was exclusively diagnosed with P. malariae through microscopy, Plasmodium genus-specific nested polymerase chain reaction (PCR), and sequencing of targeted P. malariae circumsporozoite (pmcsp) gene, except for serological RDT | ||
| 520 | |a RESULTS: The patient was discharged in stable condition after 5 days of hospitalization, with no overt malaria parasites or associated symptoms | ||
| 520 | |a CONCLUSIONS: This case reveals that asymptomatic P. malariae infections can occur among exported laborers back from malaria-endemic areas, some of whom may escape serological screening test or RDT, posing a continuing potential threat to malaria control. Therefore, PCR-based molecular techniques are more effective and necessary than serological RDT for malaria surveillance nationwide | ||
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| 700 | 1 | |a Si, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Qiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yuanhong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Bo |e verfasserin |4 aut | |
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