A deletion in the N gene may cause diagnostic escape in SARS-CoV-2 samples
Copyright © 2021. Published by Elsevier Inc..
Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:102 |
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| Enthalten in: |
Diagnostic microbiology and infectious disease - 102(2022), 1 vom: 15. Jan., Seite 115540 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zannoli, Silvia [VerfasserIn] |
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| Links: |
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| Themen: |
B.1.1.7 |
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| Anmerkungen: |
Date Completed 16.12.2021 Date Revised 16.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.diagmicrobio.2021.115540 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance | ||
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