Norfloxacin and gentamicin degradation catalyzed by manganese porphyrins under mild conditions : the importance of toxicity assessment
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
The current work assessed the degradation degree and the degradation products derived from norfloxacin (NOR) and gentamicin (GEN) using iodosylbenzene and iodobenzene diacetate, in the presence of manganese porphyrin as catalysts. Better results for NOR degradation (> 80%) were obtained when more hydrophobic porphyrins were employed. β-brominated manganese porphyrins showed a lower GEN degradation (~ 25%) than the non-brominated ones (~ 35%), probably due to their steric hindrance. In any case, complete mineralization was achieved neither for NOR nor for GEN, and the assignment of the generated products, complemented by the study of their toxicity, was an important step performed. From the obtained results, no correlation was found between the number of identified products and the reported toxicity value (rSpearman,NOR = 0.006; p value = 0.986 and rSpearman,GEN = - 0,198; p value = 0.583), which reinforces the idea of synergism and antagonistic phenomena. The higher degradation degree could have led to products of lower steric hindrance and easier penetration into the A. fischeri cells, which subsequently led to an increase in toxicity for these experiments. In most cases, the products presented higher toxicity than the original compound, which raises a concern about their occurrence in environmental matrices.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Environmental science and pollution research international - 29(2022), 11 vom: 13. März, Seite 16203-16212 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Souza Santos, Lucilaine Valéria [VerfasserIn] |
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| Links: |
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| Themen: |
42Z2K6ZL8P |
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| Anmerkungen: |
Date Completed 11.02.2022 Date Revised 11.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11356-021-16850-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a The current work assessed the degradation degree and the degradation products derived from norfloxacin (NOR) and gentamicin (GEN) using iodosylbenzene and iodobenzene diacetate, in the presence of manganese porphyrin as catalysts. Better results for NOR degradation (> 80%) were obtained when more hydrophobic porphyrins were employed. β-brominated manganese porphyrins showed a lower GEN degradation (~ 25%) than the non-brominated ones (~ 35%), probably due to their steric hindrance. In any case, complete mineralization was achieved neither for NOR nor for GEN, and the assignment of the generated products, complemented by the study of their toxicity, was an important step performed. From the obtained results, no correlation was found between the number of identified products and the reported toxicity value (rSpearman,NOR = 0.006; p value = 0.986 and rSpearman,GEN = - 0,198; p value = 0.583), which reinforces the idea of synergism and antagonistic phenomena. The higher degradation degree could have led to products of lower steric hindrance and easier penetration into the A. fischeri cells, which subsequently led to an increase in toxicity for these experiments. In most cases, the products presented higher toxicity than the original compound, which raises a concern about their occurrence in environmental matrices | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antibiotics | |
| 650 | 4 | |a Biomimetic system | |
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| 700 | 1 | |a Jacob, Raquel Sampaio |e verfasserin |4 aut | |
| 700 | 1 | |a Martins, Dayse Carvalho da Silva |e verfasserin |4 aut | |
| 700 | 1 | |a Lange, Lisete Celina |e verfasserin |4 aut | |
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