A man in his eighties with gait problems and elevated CRP
BACKGROUND: Rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hospitals is essential for early isolation and treatment. However, false positive test results can have adverse consequences for patient safety.
CASE PRESENTATION: A man in his eighties was admitted to hospital with fatigue and new-onset gait and balance difficulties, without fever or symptoms of focal infection, but with elevated C-reactive protein. On admission, he tested positive on screening for SARS-CoV-2 using a fully automated rapid reverse transcription polymerase chain reaction (RT-PCR) test. He was placed together with two patients with confirmed COVID-19 infection in cohort isolation. Due to very low exposure risk and nonspecific symptoms, the primary and multiple subsequent test swabs were analysed using RT-PCR analyses guided by laboratory personnel, and all gave negative results. The patient had several risk factors for developing severe COVID-19 illness, but fortunately he remained COVID-19 negative on repeated tests.
INTERPRETATION: The case presentation highlights the danger of false-positive SARS-CoV-2 test results, and the importance of interpreting a diagnostic test in the context of pretest probability and test accuracy. It also underlines the risk of using cohort isolation instead of individual isolation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:141 |
|---|---|
| Enthalten in: |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 141(2021), 2021-14 vom: 12. Okt. |
| Sprache: |
Norwegisch |
|---|
| Weiterer Titel: |
En mann i 80-årene med gangvansker og høy CRP-verdi |
|---|
| Beteiligte Personen: |
Berg, Åse [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 22.10.2021 Date Revised 23.11.2021 published: Electronic-Print Citation Status MEDLINE |
|---|
| doi: |
10.4045/tidsskr.21.0240 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM331824671 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM331824671 | ||
| 003 | DE-627 | ||
| 005 | 20231225214324.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||nor c | ||
| 024 | 7 | |a 10.4045/tidsskr.21.0240 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1106.xml |
| 035 | |a (DE-627)NLM331824671 | ||
| 035 | |a (NLM)34641661 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a nor | ||
| 100 | 1 | |a Berg, Åse |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A man in his eighties with gait problems and elevated CRP |
| 246 | 3 | 3 | |a En mann i 80-årene med gangvansker og høy CRP-verdi |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.10.2021 | ||
| 500 | |a Date Revised 23.11.2021 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Rapid detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hospitals is essential for early isolation and treatment. However, false positive test results can have adverse consequences for patient safety | ||
| 520 | |a CASE PRESENTATION: A man in his eighties was admitted to hospital with fatigue and new-onset gait and balance difficulties, without fever or symptoms of focal infection, but with elevated C-reactive protein. On admission, he tested positive on screening for SARS-CoV-2 using a fully automated rapid reverse transcription polymerase chain reaction (RT-PCR) test. He was placed together with two patients with confirmed COVID-19 infection in cohort isolation. Due to very low exposure risk and nonspecific symptoms, the primary and multiple subsequent test swabs were analysed using RT-PCR analyses guided by laboratory personnel, and all gave negative results. The patient had several risk factors for developing severe COVID-19 illness, but fortunately he remained COVID-19 negative on repeated tests | ||
| 520 | |a INTERPRETATION: The case presentation highlights the danger of false-positive SARS-CoV-2 test results, and the importance of interpreting a diagnostic test in the context of pretest probability and test accuracy. It also underlines the risk of using cohort isolation instead of individual isolation | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Doeland, Herman |e verfasserin |4 aut | |
| 700 | 1 | |a Fardal, Hilde |e verfasserin |4 aut | |
| 700 | 1 | |a Flørenæs, Even |e verfasserin |4 aut | |
| 700 | 1 | |a Bjørnestad, Espen Øglænd |e verfasserin |4 aut | |
| 700 | 1 | |a Lyngøy, Anita Sandmo |e verfasserin |4 aut | |
| 700 | 1 | |a Syre, Heidi |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke |d 1946 |g 141(2021), 2021-14 vom: 12. Okt. |w (DE-627)NLM00004475X |x 0807-7096 |7 nnns |
| 773 | 1 | 8 | |g volume:141 |g year:2021 |g number:2021-14 |g day:12 |g month:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4045/tidsskr.21.0240 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 141 |j 2021 |e 2021-14 |b 12 |c 10 | ||