Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients : RT-PCR swab positive and negative comparison
Copyright © 2021. Published by Elsevier Ltd..
BACKGROUND: COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative RT-PCR often presented with clinical manifestations of COVID-19. The data on such patients are lacking. The present study aims to characterize the patients who were suspected COVID-19 cases and tested negative in RT-PCR compared to patients who had been tested RT-PCR positive.
METHODS: This is a retrospective, observational study of adult suspected and confirmed patients of COVID-19 admitted to King Saud University Medical City, Riyadh, Saudi Arabia, from 1st March 2020 until 30th November 2020. Laboratory confirmation is done through nasal/pharyngeal swab specimens, tested positive in RT-PCR assay. Patients with initial negative RT-PCR test results were assessed again within 48-72 h to avoid false-negative results. Patient data were extracted from the electronic medical files of each included patient using a predesigned case report form.
RESULTS: The study included 488 (80.93%) patients with RT-PCR swab results positive, and 115 (19.07%) patients who were negative. Respiratory rate and diastolic blood pressure were higher among the swab-positive cases. More number of swab-negative patients had comorbidities such as coronary heart disease, chronic kidney disease, and carcinoma. Fever, cough, and shortness of breath were reported higher among the swab-positive cases. ALT and AST, and LDH levels were found higher among RT-PCR-positive patients. Serum creatinine, blood urea nitrogen and troponin were more elevated in RT-PCR-negative patients. Antibiotics, anticoagulants, and corticosteroids were used more by swab-positive patients. Significantly higher number of RT-PCR-positive patients required proning, high-flow nasal cannula, non-invasive mechanical ventilation, and invasive mechanical ventilation. Acute cardiac ischemia and death were found to be similar among the patients. However, deaths occurred significantly earlier among the swab-positive cases when compared to the swab-negative group.
CONCLUSION: Distinctive symptoms and markers of COVID-19 are more frequent among patients who had RT-PCR-positive results.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Journal of infection and public health - 14(2021), 11 vom: 08. Nov., Seite 1623-1629 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Alfadda, Assim A [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 10.11.2021 Date Revised 10.11.2021 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.jiph.2021.09.014 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM331656787 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM331656787 | ||
003 | DE-627 | ||
005 | 20231225213936.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.jiph.2021.09.014 |2 doi | |
028 | 5 | 2 | |a pubmed24n1105.xml |
035 | |a (DE-627)NLM331656787 | ||
035 | |a (NLM)34624717 | ||
035 | |a (PII)S1876-0341(21)00275-6 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Alfadda, Assim A |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients |b RT-PCR swab positive and negative comparison |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 10.11.2021 | ||
500 | |a Date Revised 10.11.2021 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2021. Published by Elsevier Ltd. | ||
520 | |a BACKGROUND: COVID-19 is diagnosed using RT-PCR assays of samples from nasal and oropharyngeal swabs. People with negative RT-PCR often presented with clinical manifestations of COVID-19. The data on such patients are lacking. The present study aims to characterize the patients who were suspected COVID-19 cases and tested negative in RT-PCR compared to patients who had been tested RT-PCR positive | ||
520 | |a METHODS: This is a retrospective, observational study of adult suspected and confirmed patients of COVID-19 admitted to King Saud University Medical City, Riyadh, Saudi Arabia, from 1st March 2020 until 30th November 2020. Laboratory confirmation is done through nasal/pharyngeal swab specimens, tested positive in RT-PCR assay. Patients with initial negative RT-PCR test results were assessed again within 48-72 h to avoid false-negative results. Patient data were extracted from the electronic medical files of each included patient using a predesigned case report form | ||
520 | |a RESULTS: The study included 488 (80.93%) patients with RT-PCR swab results positive, and 115 (19.07%) patients who were negative. Respiratory rate and diastolic blood pressure were higher among the swab-positive cases. More number of swab-negative patients had comorbidities such as coronary heart disease, chronic kidney disease, and carcinoma. Fever, cough, and shortness of breath were reported higher among the swab-positive cases. ALT and AST, and LDH levels were found higher among RT-PCR-positive patients. Serum creatinine, blood urea nitrogen and troponin were more elevated in RT-PCR-negative patients. Antibiotics, anticoagulants, and corticosteroids were used more by swab-positive patients. Significantly higher number of RT-PCR-positive patients required proning, high-flow nasal cannula, non-invasive mechanical ventilation, and invasive mechanical ventilation. Acute cardiac ischemia and death were found to be similar among the patients. However, deaths occurred significantly earlier among the swab-positive cases when compared to the swab-negative group | ||
520 | |a CONCLUSION: Distinctive symptoms and markers of COVID-19 are more frequent among patients who had RT-PCR-positive results | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Observational Study | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Clinical characteristics | |
650 | 4 | |a Negative RT-PCR | |
650 | 4 | |a Suspected COVID-19 | |
700 | 1 | |a AlKhowaiter, Mohammad |e verfasserin |4 aut | |
700 | 1 | |a Alotaibi, Naif |e verfasserin |4 aut | |
700 | 1 | |a Alayed, Khalid |e verfasserin |4 aut | |
700 | 1 | |a Alzahrani, Musa |e verfasserin |4 aut | |
700 | 1 | |a Binkhamis, Khalifa |e verfasserin |4 aut | |
700 | 1 | |a Siddiqui, Khalid |e verfasserin |4 aut | |
700 | 1 | |a Youssef, Amira |e verfasserin |4 aut | |
700 | 1 | |a Altalhi, Haifa |e verfasserin |4 aut | |
700 | 1 | |a Almaghlouth, Ibrahim |e verfasserin |4 aut | |
700 | 1 | |a Alarifi, Mohammed |e verfasserin |4 aut | |
700 | 1 | |a Albanyan, Saleh |e verfasserin |4 aut | |
700 | 1 | |a Alosaimi, Mohammed Faraj |e verfasserin |4 aut | |
700 | 1 | |a Hasanato, Rana |e verfasserin |4 aut | |
700 | 1 | |a Isnani, Arthur |e verfasserin |4 aut | |
700 | 1 | |a Dekhil, Hafedh |e verfasserin |4 aut | |
700 | 1 | |a Rafiullah, Mohamed |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of infection and public health |d 2008 |g 14(2021), 11 vom: 08. Nov., Seite 1623-1629 |w (DE-627)NLM200240730 |x 1876-035X |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2021 |g number:11 |g day:08 |g month:11 |g pages:1623-1629 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jiph.2021.09.014 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 14 |j 2021 |e 11 |b 08 |c 11 |h 1623-1629 |