Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination
© 2021. The Author(s)..
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found in variants of concern1. As a result, vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals with currently available mRNA vaccines produces high levels of plasma neutralizing activity against all variants tested1,2. Here we examine memory B cell evolution five months after vaccination with either Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) mRNA vaccine in a cohort of SARS-CoV-2-naive individuals. Between prime and boost, memory B cells produce antibodies that evolve increased neutralizing activity, but there is no further increase in potency or breadth thereafter. Instead, memory B cells that emerge five months after vaccination of naive individuals express antibodies that are similar to those that dominate the initial response. While individual memory antibodies selected over time by natural infection have greater potency and breadth than antibodies elicited by vaccination, the overall neutralizing potency of plasma is greater following vaccination. These results suggest that boosting vaccinated individuals with currently available mRNA vaccines will increase plasma neutralizing activity but may not produce antibodies with equivalent breadth to those obtained by vaccinating convalescent individuals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:600 |
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| Enthalten in: |
Nature - 600(2021), 7889 vom: 07. Dez., Seite 517-522 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cho, Alice [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.01.2022 Date Revised 29.02.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41586-021-04060-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination |
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| 500 | |a Date Completed 11.01.2022 | ||
| 500 | |a Date Revised 29.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found in variants of concern1. As a result, vaccination of coronavirus disease 2019 (COVID-19) convalescent individuals with currently available mRNA vaccines produces high levels of plasma neutralizing activity against all variants tested1,2. Here we examine memory B cell evolution five months after vaccination with either Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) mRNA vaccine in a cohort of SARS-CoV-2-naive individuals. Between prime and boost, memory B cells produce antibodies that evolve increased neutralizing activity, but there is no further increase in potency or breadth thereafter. Instead, memory B cells that emerge five months after vaccination of naive individuals express antibodies that are similar to those that dominate the initial response. While individual memory antibodies selected over time by natural infection have greater potency and breadth than antibodies elicited by vaccination, the overall neutralizing potency of plasma is greater following vaccination. These results suggest that boosting vaccinated individuals with currently available mRNA vaccines will increase plasma neutralizing activity but may not produce antibodies with equivalent breadth to those obtained by vaccinating convalescent individuals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antibodies, Monoclonal |2 NLM | |
| 650 | 7 | |a Antibodies, Neutralizing |2 NLM | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 650 | 7 | |a COVID-19 Vaccines |2 NLM | |
| 650 | 7 | |a Epitopes, B-Lymphocyte |2 NLM | |
| 650 | 7 | |a Spike Glycoprotein, Coronavirus |2 NLM | |
| 650 | 7 | |a Vaccines, Synthetic |2 NLM | |
| 650 | 7 | |a mRNA Vaccines |2 NLM | |
| 650 | 7 | |a spike protein, SARS-CoV-2 |2 NLM | |
| 650 | 7 | |a 2019-nCoV Vaccine mRNA-1273 |2 NLM | |
| 650 | 7 | |a EPK39PL4R4 |2 NLM | |
| 650 | 7 | |a BNT162 Vaccine |2 NLM | |
| 650 | 7 | |a N38TVC63NU |2 NLM | |
| 700 | 1 | |a Muecksch, Frauke |e verfasserin |4 aut | |
| 700 | 1 | |a Schaefer-Babajew, Dennis |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zijun |e verfasserin |4 aut | |
| 700 | 1 | |a Finkin, Shlomo |e verfasserin |4 aut | |
| 700 | 1 | |a Gaebler, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Cipolla, Melissa |e verfasserin |4 aut | |
| 700 | 1 | |a Mendoza, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Agudelo, Marianna |e verfasserin |4 aut | |
| 700 | 1 | |a Bednarski, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a DaSilva, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Shimeliovich, Irina |e verfasserin |4 aut | |
| 700 | 1 | |a Dizon, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Daga, Mridushi |e verfasserin |4 aut | |
| 700 | 1 | |a Millard, Katrina G |e verfasserin |4 aut | |
| 700 | 1 | |a Turroja, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Fabian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Fengwen |e verfasserin |4 aut | |
| 700 | 1 | |a Tanfous, Tarek Ben |e verfasserin |4 aut | |
| 700 | 1 | |a Jankovic, Mila |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveria, Thiago Y |e verfasserin |4 aut | |
| 700 | 1 | |a Gazumyan, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Caskey, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Bieniasz, Paul D |e verfasserin |4 aut | |
| 700 | 1 | |a Hatziioannou, Theodora |e verfasserin |4 aut | |
| 700 | 1 | |a Nussenzweig, Michel C |e verfasserin |4 aut | |
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