Altered Polarization and Impaired Phagocytic Activity of Lung Macrophages in People With Human Immunodeficiency Virus and Chronic Obstructive Pulmonary Disease
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: People with human immunodeficiency virus (PWH) have an increased risk of developing chronic obstructive pulmonary disease (COPD).
METHODS: We phenotyped lung macrophages in 4 subgroups-M1 (CD40+CD163-), M2 (CD40-CD163+), double positives (CD40+CD163+), and double negatives and (CD40-CD163-)-and we determined their phagocytic capacity in PWH with and without COPD.
RESULTS: People with human immunodeficiency virus with COPD have more double-negative macrophages (84.1%) versus PWH without (54.3%) versus controls (23.9%) (P=.004) and reduced phagocytosis (P=.012). Double-negative macrophages had the worst phagocytic capacity (P<.001).
CONCLUSIONS: People with human immunodeficiency virus with COPD have an abundance of nonpolarized macrophages, which have poor phagocytic capacity and therefore predispose PWH to increased risk of disease progression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:225 |
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| Enthalten in: |
The Journal of infectious diseases - 225(2022), 5 vom: 02. März, Seite 862-867 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Akata, Kentaro [VerfasserIn] |
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| Links: |
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| Themen: |
COPD |
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| Anmerkungen: |
Date Completed 09.05.2022 Date Revised 09.05.2022 published: Print ClinicalTrials.gov: NCT02833480 Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiab506 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM331513315 |
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| 245 | 1 | 0 | |a Altered Polarization and Impaired Phagocytic Activity of Lung Macrophages in People With Human Immunodeficiency Virus and Chronic Obstructive Pulmonary Disease |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 09.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT02833480 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND: People with human immunodeficiency virus (PWH) have an increased risk of developing chronic obstructive pulmonary disease (COPD) | ||
| 520 | |a METHODS: We phenotyped lung macrophages in 4 subgroups-M1 (CD40+CD163-), M2 (CD40-CD163+), double positives (CD40+CD163+), and double negatives and (CD40-CD163-)-and we determined their phagocytic capacity in PWH with and without COPD | ||
| 520 | |a RESULTS: People with human immunodeficiency virus with COPD have more double-negative macrophages (84.1%) versus PWH without (54.3%) versus controls (23.9%) (P=.004) and reduced phagocytosis (P=.012). Double-negative macrophages had the worst phagocytic capacity (P<.001) | ||
| 520 | |a CONCLUSIONS: People with human immunodeficiency virus with COPD have an abundance of nonpolarized macrophages, which have poor phagocytic capacity and therefore predispose PWH to increased risk of disease progression | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a PWH | |
| 650 | 4 | |a lung macrophages | |
| 650 | 4 | |a phagocytosis | |
| 650 | 4 | |a phenotype | |
| 700 | 1 | |a Leung, Janice M |e verfasserin |4 aut | |
| 700 | 1 | |a Yamasaki, Kei |e verfasserin |4 aut | |
| 700 | 1 | |a Leitao Filho, Fernando S |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Xi Yang, Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Takiguchi, Hiroto |e verfasserin |4 aut | |
| 700 | 1 | |a Shaipanich, Tawimas |e verfasserin |4 aut | |
| 700 | 1 | |a Sahin, Basak |e verfasserin |4 aut | |
| 700 | 1 | |a Whalen, Beth A |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Cheng Wei Tony |e verfasserin |4 aut | |
| 700 | 1 | |a Sin, Don D |e verfasserin |4 aut | |
| 700 | 1 | |a van Eeden, Stephan F |e verfasserin |4 aut | |
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